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10.3324/haematol.2015.124321 http://scihub22266oqcxt.onion/10.3324/haematol.2015.124321 C4800704!4800704!26069293     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Haematologica 2015 ; 100 (9): 1151-9 Nephropedia Template TP {{tp|p=26069293|t=2015. Recurrent deletions of IKZF1 in pediatric acute myeloid leukemia |pdf=|usr=}}{{26069293}} gab.com Text Recurrent deletions of IKZF1 in pediatric acute myeloid leukemia JO: Haematologica http://www.kidney.de/pget.php?&tw=1&pmid=26069293 #FOAvip IKAROS family zinc finger 1/IKZF1 is a transcription factor important in lymphoid differentiation, and a known tumor suppressor in acute lymphoid leukemia. Recent studies suggest that IKZF1 is also involved in myeloid differentiation. To investigate whether IKZF1 deletions also play a role in pediatric acute myeloid leukemia, we screened a panel of pediatric acute myeloid leukemia samples for deletions of the IKZF1 locus using multiplex ligation-dependent probe amplification and for mutations using direct sequencing. Three patients were identified with a single amino acid variant without change of IKZF1 length. No frame-shift mutations were found. Out of 11 patients with an IKZF1 deletion, 8 samples revealed a complete loss of chromosome 7, and 3 cases a focal deletion of 0.1?0.9Mb. These deletions included the complete IKZF1 gene (n=2) or exons 1?4 (n=1), all leading to a loss of IKZF1 function. Interestingly, differentially expressed genes in monosomy 7 cases (n=8) when compared to non-deleted samples (n=247) significantly correlated with gene expression changes in focal IKZF1-deleted cases (n=3). Genes with increased expression included genes involved in myeloid cell self-renewal and cell cycle, and a significant portion of GATA target genes and GATA factors. Together, these results suggest that loss of IKZF1 is recurrent in pediatric acute myeloid leukemia and might be a determinant of oncogenesis in acute myeloid leukemia with monosomy 7 Twit Text FOAVip Recurrent deletions of IKZF1 in pediatric acute myeloid leukemia ????Haematologica http://www.kidney.de/pget.php?&tw=1&pmid=26069293 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26069293 #FOAvip English Wikipedia <ref>{{Cite pmid|26069293}}</ref> Recurrent deletions of IKZF1 in pediatric acute myeloid leukemia #MMPMID26069293 de Rooij JD; Beuling E; van den Heuvel-Eibrink MM; Obulkasim A; Baruchel A; Trka J; Reinhardt D; Sonneveld E; Gibson BE; Pieters R; Zimmermann M; Zwaan CM; Fornerod M Haematologica 2015[Sep]; 100 (9): 1151-9 PMID26069293show ga IKAROS family zinc finger 1/IKZF1 is a transcription factor important in lymphoid differentiation, and a known tumor suppressor in acute lymphoid leukemia. Recent studies suggest that IKZF1 is also involved in myeloid differentiation. To investigate whether IKZF1 deletions also play a role in pediatric acute myeloid leukemia, we screened a panel of pediatric acute myeloid leukemia samples for deletions of the IKZF1 locus using multiplex ligation-dependent probe amplification and for mutations using direct sequencing. Three patients were identified with a single amino acid variant without change of IKZF1 length. No frame-shift mutations were found. Out of 11 patients with an IKZF1 deletion, 8 samples revealed a complete loss of chromosome 7, and 3 cases a focal deletion of 0.1?0.9Mb. These deletions included the complete IKZF1 gene (n=2) or exons 1?4 (n=1), all leading to a loss of IKZF1 function. Interestingly, differentially expressed genes in monosomy 7 cases (n=8) when compared to non-deleted samples (n=247) significantly correlated with gene expression changes in focal IKZF1-deleted cases (n=3). Genes with increased expression included genes involved in myeloid cell self-renewal and cell cycle, and a significant portion of GATA target genes and GATA factors. Together, these results suggest that loss of IKZF1 is recurrent in pediatric acute myeloid leukemia and might be a determinant of oncogenesis in acute myeloid leukemia with monosomy 7 äRecurrent deletions of IKZF1 in pediatric acute myeloid leukemia (epmc).pdf DeepDyve Pubget Overpricing