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10.1161/CIRCRESAHA.115.306565 http://scihub22266oqcxt.onion/10.1161/CIRCRESAHA.115.306565 C4800485!4800485!26987915     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26987915&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       Circ+Res 2016 ; 118 (6): 1021-40 Nephropedia Template TP {{tp|p=26987915|t=2016. Cardiac Fibrosis: The Fibroblast Awakens |pdf=|usr=}}{{26987915}} gab.com Text Cardiac Fibrosis: The Fibroblast Awakens JO: Circ Res http://www.kidney.de/pget.php?&tw=1&pmid=26987915 #FOAvip Myocardial fibrosis is a significant global health problem associated with nearly all forms of heart disease. Cardiac fibroblasts comprise an essential cell type in the heart that is responsible for the homeostasis of the extracellular matrix; however upon injury, these cells transform to a myofibroblast phenotype and contribute to cardiac fibrosis. This remodeling involves pathological changes that include chamber dilation, cardiomyocyte hypertrophy and apoptosis, and ultimately leads to the progression to heart failure. Despite the critical importance of fibrosis in cardiovascular disease, our limited understanding of this cell population impedes the development of potential therapies that effectively target this cell type and its pathological contribution to disease progression. This review summarizes current knowledge regarding the origins and roles of fibroblasts, mediators and signaling pathways known to influence fibroblast function after myocardial injury, as well as novel therapeutic strategies under investigation to attenuate cardiac fibrosis. Twit Text FOAVip Cardiac Fibrosis: The Fibroblast Awakens ????Circ Res http://www.kidney.de/pget.php?&tw=1&pmid=26987915 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26987915 #FOAvip English Wikipedia <ref>{{Cite pmid|26987915}}</ref> Cardiac Fibrosis: The Fibroblast Awakens #MMPMID26987915 Travers JG; Kamal FA; Robbins J; Yutzey KE; Blaxall BC Circ Res 2016[Mar]; 118 (6): 1021-40 PMID26987915show ga Myocardial fibrosis is a significant global health problem associated with nearly all forms of heart disease. Cardiac fibroblasts comprise an essential cell type in the heart that is responsible for the homeostasis of the extracellular matrix; however upon injury, these cells transform to a myofibroblast phenotype and contribute to cardiac fibrosis. This remodeling involves pathological changes that include chamber dilation, cardiomyocyte hypertrophy and apoptosis, and ultimately leads to the progression to heart failure. Despite the critical importance of fibrosis in cardiovascular disease, our limited understanding of this cell population impedes the development of potential therapies that effectively target this cell type and its pathological contribution to disease progression. This review summarizes current knowledge regarding the origins and roles of fibroblasts, mediators and signaling pathways known to influence fibroblast function after myocardial injury, as well as novel therapeutic strategies under investigation to attenuate cardiac fibrosis. äCardiac Fibrosis: The Fibroblast Awakens (epmc).pdf DeepDyve Pubget Overpricing