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10.1038/bjc.2016.36 http://scihub22266oqcxt.onion/10.1038/bjc.2016.36 C4800301!4800301!26908329     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Br+J+Cancer 2016 ; 114 (6): 605-11 Nephropedia Template TP {{tp|p=26908329|t=2016. Inhibition of histone deacetylases in cancer therapy: lessons from leukaemia |pdf=|usr=}}{{26908329}} gab.com Text Inhibition of histone deacetylases in cancer therapy: lessons from leukaemia JO: Br J Cancer http://www.kidney.de/pget.php?&tw=1&pmid=26908329 #FOAvip Histone deacetylases (HDACs) are a key component of the epigenetic machinery regulating gene expression, and behave as oncogenes in several cancer types, spurring the development of HDAC inhibitors (HDACi) as anticancer drugs. This review discusses new results regarding the role of HDACs in cancer and the effect of HDACi on tumour cells, focusing on haematological malignancies, particularly acute myeloid leukaemia. Histone deacetylases may have opposite roles at different stages of tumour progression and in different tumour cell sub-populations (cancer stem cells), highlighting the importance of investigating these aspects for further improving the clinical use of HDACi in treating cancer. Twit Text FOAVip Inhibition of histone deacetylases in cancer therapy: lessons from leukaemia ????Br J Cancer http://www.kidney.de/pget.php?&tw=1&pmid=26908329 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26908329 #FOAvip English Wikipedia <ref>{{Cite pmid|26908329}}</ref> Inhibition of histone deacetylases in cancer therapy: lessons from leukaemia #MMPMID26908329 Ceccacci E; Minucci S Br J Cancer 2016[Mar]; 114 (6): 605-11 PMID26908329show ga Histone deacetylases (HDACs) are a key component of the epigenetic machinery regulating gene expression, and behave as oncogenes in several cancer types, spurring the development of HDAC inhibitors (HDACi) as anticancer drugs. This review discusses new results regarding the role of HDACs in cancer and the effect of HDACi on tumour cells, focusing on haematological malignancies, particularly acute myeloid leukaemia. Histone deacetylases may have opposite roles at different stages of tumour progression and in different tumour cell sub-populations (cancer stem cells), highlighting the importance of investigating these aspects for further improving the clinical use of HDACi in treating cancer. äInhibition of histone deacetylases in cancer therapy: lessons from leu(epmc).pdf DeepDyve Pubget Overpricing