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10.1016/j.ajhg.2016.02.003 http://scihub22266oqcxt.onion/10.1016/j.ajhg.2016.02.003 C4800050!4800050!26942289     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Am+J+Hum+Genet 2016 ; 98 (3): 571-8 Nephropedia Template TP {{tp|p=26942289|t=2016. Extensive Hidden Genomic Mosaicism Revealed in Normal Tissue |pdf=|usr=}}{{26942289}} gab.com Text Extensive Hidden Genomic Mosaicism Revealed in Normal Tissue JO: Am J Hum Genet http://www.kidney.de/pget.php?&tw=1&pmid=26942289 #FOAvip Genomic mosaicism arising from post-zygotic mutation has recently been demonstrated to occur in normal tissue of individuals ascertained with varied phenotypes, indicating that detectable mosaicism may be less an exception than a rule in the general population. A challenge to comprehensive cataloging of mosaic mutations and their consequences is the presence of heterogeneous mixtures of cells, rendering low-frequency clones difficult to discern. Here we applied a computational method using estimated haplotypes to characterize mosaic megabase-scale structural mutations in 31,100 GWA study subjects. We provide in silico validation of 293 previously identified somatic mutations and identify an additional 794 novel mutations, most of which exist at lower aberrant cell fractions than have been demonstrated in previous surveys. These mutations occurred across the genome but in a nonrandom manner, and several chromosomes and loci showed unusual levels of mutation. Our analysis supports recent findings about the relationship between clonal mosaicism and old age. Finally, our results, in which we demonstrate a nearly 3-fold higher rate of clonal mosaicism, suggest that SNP-based population surveys of mosaic structural mutations should be conducted with haplotypes for optimal discovery. Twit Text FOAVip Extensive Hidden Genomic Mosaicism Revealed in Normal Tissue ????Am J Hum Genet http://www.kidney.de/pget.php?&tw=1&pmid=26942289 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26942289 #FOAvip English Wikipedia <ref>{{Cite pmid|26942289}}</ref> Extensive Hidden Genomic Mosaicism Revealed in Normal Tissue #MMPMID26942289 Vattathil S; Scheet P Am J Hum Genet 2016[Mar]; 98 (3): 571-8 PMID26942289show ga Genomic mosaicism arising from post-zygotic mutation has recently been demonstrated to occur in normal tissue of individuals ascertained with varied phenotypes, indicating that detectable mosaicism may be less an exception than a rule in the general population. A challenge to comprehensive cataloging of mosaic mutations and their consequences is the presence of heterogeneous mixtures of cells, rendering low-frequency clones difficult to discern. Here we applied a computational method using estimated haplotypes to characterize mosaic megabase-scale structural mutations in 31,100 GWA study subjects. We provide in silico validation of 293 previously identified somatic mutations and identify an additional 794 novel mutations, most of which exist at lower aberrant cell fractions than have been demonstrated in previous surveys. These mutations occurred across the genome but in a nonrandom manner, and several chromosomes and loci showed unusual levels of mutation. Our analysis supports recent findings about the relationship between clonal mosaicism and old age. Finally, our results, in which we demonstrate a nearly 3-fold higher rate of clonal mosaicism, suggest that SNP-based population surveys of mosaic structural mutations should be conducted with haplotypes for optimal discovery. äExtensive Hidden Genomic Mosaicism Revealed in Normal Tissue (epmc).pdf DeepDyve Pubget Overpricing