Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1111/imm.12578 http://scihub22266oqcxt.onion/10.1111/imm.12578 C4799890!4799890!26749055     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26749055&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Immunology 2016 ; 147 (4): 453-63 Nephropedia Template TP {{tp|p=26749055|t=2016. The atypical I?B protein I?BNS is important for Toll?like receptor?induced interleukin?10 production in B cells |pdf=|usr=}}{{26749055}} gab.com Text The atypical I B protein I BNS is important for Toll like receptor induced interleukin 10 production in B cells JO: Immunology http://www.kidney.de/pget.php?&tw=1&pmid=26749055 #FOAvip Although a major function of B cells is to mediate humoral immunity by producing antigen?specific antibodies, a specific subset of B cells is important for immune suppression, which is mainly mediated by the secretion of the anti?inflammatory cytokine interleukin?10 (IL?10). However, the mechanism by which IL?10 is induced in B cells has not been fully elucidated. Here, we report that I?BNS, an inducible nuclear I?B protein, is important for Toll?like receptor (TLR)?mediated IL?10 production in B cells. Studies using I?BNS knockout mice revealed that the number of IL?10?producing B cells is reduced in I?BNS?/? spleens and that the TLR?mediated induction of cytoplasmic IL?10?positive cells and IL?10 secretion in B cells are impaired in the absence of I?BNS. The impairment of IL?10 production by a lack of I?BNS was not observed in TLR?triggered macrophages or T?cell?receptor?stimulated CD4+CD25+ T cells. In addition, I?BNS?deficient B cells showed reduced expression of Prdm1 and Irf4 and failed to generate IL?10+CD138+ plasmablasts. These results suggest that I?BNS is selectively required for IL?10 production in B cells responding to TLR signals, so defining an additional role for I?BNS in the control of the B?cell?mediated immune responses. Twit Text FOAVip The atypical I B protein I BNS is important for Toll like receptor induced interleukin 10 production in B cells ????Immunology http://www.kidney.de/pget.php?&tw=1&pmid=26749055 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26749055 #FOAvip English Wikipedia <ref>{{Cite pmid|26749055}}</ref> The atypical I?B protein I?BNS is important for Toll?like receptor?induced interleukin?10 production in B cells #MMPMID26749055 Miura M; Hasegawa N; Noguchi M; Sugimoto K; Touma M Immunology 2016[Apr]; 147 (4): 453-63 PMID26749055show ga Although a major function of B cells is to mediate humoral immunity by producing antigen?specific antibodies, a specific subset of B cells is important for immune suppression, which is mainly mediated by the secretion of the anti?inflammatory cytokine interleukin?10 (IL?10). However, the mechanism by which IL?10 is induced in B cells has not been fully elucidated. Here, we report that I?BNS, an inducible nuclear I?B protein, is important for Toll?like receptor (TLR)?mediated IL?10 production in B cells. Studies using I?BNS knockout mice revealed that the number of IL?10?producing B cells is reduced in I?BNS?/? spleens and that the TLR?mediated induction of cytoplasmic IL?10?positive cells and IL?10 secretion in B cells are impaired in the absence of I?BNS. The impairment of IL?10 production by a lack of I?BNS was not observed in TLR?triggered macrophages or T?cell?receptor?stimulated CD4+CD25+ T cells. In addition, I?BNS?deficient B cells showed reduced expression of Prdm1 and Irf4 and failed to generate IL?10+CD138+ plasmablasts. These results suggest that I?BNS is selectively required for IL?10 production in B cells responding to TLR signals, so defining an additional role for I?BNS in the control of the B?cell?mediated immune responses. äThe atypical I?B protein I?BNS is important for Toll?like receptor?ind(epmc).pdf DeepDyve Pubget Overpricing