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10.1111/imm.12580 http://scihub22266oqcxt.onion/10.1111/imm.12580 C4799889!4799889 !26749286     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26749286 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Immunology 2016 ; 147 (4 ): 476-87 Nephropedia Template TP {{tp|p=26749286 |t=2016. Gfi1, a transcriptional repressor, inhibits the induction of the T helper type 1 programme in activated CD4 T cells |pdf=|usr=}}{{26749286 }} gab.com Text Gfi1, a transcriptional repressor, inhibits the induction of the T helper type 1 programme in activated CD4 T cells JO: Immunology http://www.kidney.de/pget.php?&tw=1&pmid=26749286 #FOAvip A transcriptional repressor Gfi1 promotes T helper type 2 (Th2) cell development and inhibits Th17 and inducible regulatory T-cell differentiation. However, the role of Gfi1 in regulating Th1 cell differentiation and the Th1-type immune response remains to be investigated. We herein demonstrate that Gfi1 inhibits the induction of the Th1 programme in activated CD4 T cells. The activated Gfi1-deficient CD4 T cells spontaneously develop into Th1 cells in an interleukin-12- and interferon-?-independent manner. The increase of Th1-type immune responses was confirmed in vivo in Gfi1-deficient mice using a murine model of nickel allergy and delayed-type hypersensitivity (DTH). The expression levels of Th1-related transcription factors were found to increase in Gfi1-deficient activated CD4 T cells. Tbx21, Eomes and Runx2 were identified as possible direct targets of Gfi1. Gfi1 binds to the Tbx21, Eomes and Runx2 gene loci and reduces the histone H3K4 methylation levels in part by modulating Lsd1 recruitment. Together, these findings demonstrate a novel regulatory role of Gfi1 in the regulation of the Th1-type immune response. Twit Text FOAVip Gfi1, a transcriptional repressor, inhibits the induction of the T helper type 1 programme in activated CD4 T cells ????Immunology http://www.kidney.de/pget.php?&tw=1&pmid=26749286 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26749286 #FOAvip English Wikipedia <ref>{{Cite pmid|26749286 }}</ref> Gfi1, a transcriptional repressor, inhibits the induction of the T helper type 1 programme in activated CD4 T cells #MMPMID26749286 Suzuki J ; Maruyama S ; Tamauchi H ; Kuwahara M ; Horiuchi M ; Mizuki M ; Ochi M ; Sawasaki T ; Zhu J ; Yasukawa M ; Yamashita M Immunology 2016[Apr]; 147 (4 ): 476-87 PMID26749286 show ga A transcriptional repressor Gfi1 promotes T helper type 2 (Th2) cell development and inhibits Th17 and inducible regulatory T-cell differentiation. However, the role of Gfi1 in regulating Th1 cell differentiation and the Th1-type immune response remains to be investigated. We herein demonstrate that Gfi1 inhibits the induction of the Th1 programme in activated CD4 T cells. The activated Gfi1-deficient CD4 T cells spontaneously develop into Th1 cells in an interleukin-12- and interferon-?-independent manner. The increase of Th1-type immune responses was confirmed in vivo in Gfi1-deficient mice using a murine model of nickel allergy and delayed-type hypersensitivity (DTH). The expression levels of Th1-related transcription factors were found to increase in Gfi1-deficient activated CD4 T cells. Tbx21, Eomes and Runx2 were identified as possible direct targets of Gfi1. Gfi1 binds to the Tbx21, Eomes and Runx2 gene loci and reduces the histone H3K4 methylation levels in part by modulating Lsd1 recruitment. Together, these findings demonstrate a novel regulatory role of Gfi1 in the regulation of the Th1-type immune response. |Animals [MESH] |CD4-Positive T-Lymphocytes/cytology/*immunology/*metabolism [MESH] |Cell Differentiation/genetics/immunology [MESH] |Core Binding Factor Alpha 1 Subunit/genetics [MESH] |Cytokines/metabolism [MESH] |DNA-Binding Proteins/deficiency/*genetics/metabolism [MESH] |Gene Expression [MESH] |Histone Demethylases/antagonists & inhibitors [MESH] |Histones/metabolism [MESH] |Interferon-gamma/biosynthesis [MESH] |Lymphocyte Activation/*genetics/*immunology [MESH] |Methylation [MESH] |Mice [MESH] |Mice, Knockout [MESH] |Mice, Transgenic [MESH] |Protein Binding [MESH] |T-Box Domain Proteins/genetics [MESH] |T-bet Transcription Factor [MESH] |Th1 Cells/cytology/*immunology/*metabolism [MESH]Gfi1, a transcriptional repressor, inhibits the induction of the T hel(epmc).pdf DeepDyve Pubget Overpricing