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10.1111/imm.12571 http://scihub22266oqcxt.onion/10.1111/imm.12571 C4799882!4799882!26694999     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Immunology 2016 ; 147 (4): 414-28 Nephropedia Template TP {{tp|p=26694999|t=2016. Interleukin?17A neutralization alleviated ocular neovascularization by promoting M2 and mitigating M1 macrophage polarization |pdf=|usr=}}{{26694999}} gab.com Text Interleukin 17A neutralization alleviated ocular neovascularization by promoting M2 and mitigating M1 macrophage polarization JO: Immunology http://www.kidney.de/pget.php?&tw=1&pmid=26694999 #FOAvip Neovascularization (NV), as a cardinal complication of several ocular diseases, has been intensively studied, and research has shown its close association with inflammation and immune cells. In the present study, the role of interleukin?17A (IL?17A) in angiogenesis in the process of ocular NV both in vivo and in vitro was investigated. Also, a paracrine role of IL?17A was demonstrated in the crosstalk between endothelial cells and macrophages in angiogenesis. In the retinas of mice with retinopathy of prematurity, the IL?17A expression increased significantly at postnatal day 15 (P15) and P18 during retinal NV. Mice given IL?17A neutralizing antibody (NAb) developed significantly reduced choroidal NV and retinal NV. Studies on vascular endothelial growth factor (VEGF) over?expressing mice suggested that IL?17A modulated NV through the VEGF pathway. Furthermore, IL?17A deficiency shifted macrophage polarization toward an M2 phenotype during retinal NV with significantly reduced M1 cytokine expression compared with wild?type controls. In vitro assays revealed that IL?17A treated macrophage supernatant gave rise to elevated human umbilical vascular endothelial cell proliferation, tube formation and VEGF receptor 1 and receptor 2 expression. Therefore, IL?17A could potentially serve as a novel target for treating ocular NV diseases. The limitation of this study involved the potential mechanisms, such as which transcription accounted for macrophage polarization and how the subsequent cytokines were modulated when macrophages were polarized. Further studies need to be undertaken to definitively determine the extent to which IL?17A neutralizing anti?angiogenic activity depends on macrophage modulation compared with anti?VEGF treatment. Twit Text FOAVip Interleukin 17A neutralization alleviated ocular neovascularization by promoting M2 and mitigating M1 macrophage polarization ????Immunology http://www.kidney.de/pget.php?&tw=1&pmid=26694999 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26694999 #FOAvip English Wikipedia <ref>{{Cite pmid|26694999}}</ref> Interleukin?17A neutralization alleviated ocular neovascularization by promoting M2 and mitigating M1 macrophage polarization #MMPMID26694999 Zhu Y; Tan W; Demetriades AM; Cai Y; Gao Y; Sui A; Lu Q; Shen X; Jiang C; Xie B; Sun X Immunology 2016[Apr]; 147 (4): 414-28 PMID26694999show ga Neovascularization (NV), as a cardinal complication of several ocular diseases, has been intensively studied, and research has shown its close association with inflammation and immune cells. In the present study, the role of interleukin?17A (IL?17A) in angiogenesis in the process of ocular NV both in vivo and in vitro was investigated. Also, a paracrine role of IL?17A was demonstrated in the crosstalk between endothelial cells and macrophages in angiogenesis. In the retinas of mice with retinopathy of prematurity, the IL?17A expression increased significantly at postnatal day 15 (P15) and P18 during retinal NV. Mice given IL?17A neutralizing antibody (NAb) developed significantly reduced choroidal NV and retinal NV. Studies on vascular endothelial growth factor (VEGF) over?expressing mice suggested that IL?17A modulated NV through the VEGF pathway. Furthermore, IL?17A deficiency shifted macrophage polarization toward an M2 phenotype during retinal NV with significantly reduced M1 cytokine expression compared with wild?type controls. In vitro assays revealed that IL?17A treated macrophage supernatant gave rise to elevated human umbilical vascular endothelial cell proliferation, tube formation and VEGF receptor 1 and receptor 2 expression. Therefore, IL?17A could potentially serve as a novel target for treating ocular NV diseases. The limitation of this study involved the potential mechanisms, such as which transcription accounted for macrophage polarization and how the subsequent cytokines were modulated when macrophages were polarized. Further studies need to be undertaken to definitively determine the extent to which IL?17A neutralizing anti?angiogenic activity depends on macrophage modulation compared with anti?VEGF treatment. äInterleukin?17A neutralization alleviated ocular neovascularization by(epmc).pdf DeepDyve Pubget Overpricing