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10.1186/s13063-016-1273-9 http://scihub22266oqcxt.onion/10.1186/s13063-016-1273-9 C4799596!4799596!26993469     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Trials 2016 ; 17 (ä): ä Nephropedia Template TP {{tp|p=26993469|t=2016. Adaptive designs undertaken in clinical research: a review of registered clinical trials |pdf=|usr=}}{{26993469}} gab.com Text Adaptive designs undertaken in clinical research: a review of registered clinical trials JO: Trials http://www.kidney.de/pget.php?&tw=1&pmid=26993469 #FOAvip Adaptive designs have the potential to improve efficiency in the evaluation of new medical treatments in comparison to traditional fixed sample size designs. However, they are still not widely used in practice in clinical research. Little research has been conducted to investigate what adaptive designs are being undertaken. This review highlights the current state of registered adaptive designs and their characteristics. The review looked at phase II, II/III and III trials registered on ClinicalTrials.gov from 29 February 2000 to 1 June 2014, supplemented with trials from the National Institute for Health Research register and known adaptive trials. A range of adaptive design search terms were applied to the trials extracted from each database. Characteristics of the adaptive designs were then recorded including funder, therapeutic area and type of adaptation. The results in the paper suggest that the use of adaptive designs has increased. They seem to be most often used in phase II trials and in oncology. In phase III trials, the most popular form of adaptation is the group sequential design. The review failed to capture all trials with adaptive designs, which suggests that the reporting of adaptive designs, such as in clinical trials registers, needs much improving. We recommend that clinical trial registers should contain sections dedicated to the type and scope of the adaptation and that the term ?adaptive design? should be included in the trial title or at least in the brief summary or design sections.Electronic supplementary material: The online version of this article (doi:10.1186/s13063-016-1273-9) contains supplementary material, which is available to authorized users. Twit Text FOAVip Adaptive designs undertaken in clinical research: a review of registered clinical trials ????Trials http://www.kidney.de/pget.php?&tw=1&pmid=26993469 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26993469 #FOAvip English Wikipedia <ref>{{Cite pmid|26993469}}</ref> Adaptive designs undertaken in clinical research: a review of registered clinical trials #MMPMID26993469 Hatfield I; Allison A; Flight L; Julious SA; Dimairo M Trials 2016[]; 17 (ä): ä PMID26993469show ga Adaptive designs have the potential to improve efficiency in the evaluation of new medical treatments in comparison to traditional fixed sample size designs. However, they are still not widely used in practice in clinical research. Little research has been conducted to investigate what adaptive designs are being undertaken. This review highlights the current state of registered adaptive designs and their characteristics. The review looked at phase II, II/III and III trials registered on ClinicalTrials.gov from 29 February 2000 to 1 June 2014, supplemented with trials from the National Institute for Health Research register and known adaptive trials. A range of adaptive design search terms were applied to the trials extracted from each database. Characteristics of the adaptive designs were then recorded including funder, therapeutic area and type of adaptation. The results in the paper suggest that the use of adaptive designs has increased. They seem to be most often used in phase II trials and in oncology. In phase III trials, the most popular form of adaptation is the group sequential design. The review failed to capture all trials with adaptive designs, which suggests that the reporting of adaptive designs, such as in clinical trials registers, needs much improving. We recommend that clinical trial registers should contain sections dedicated to the type and scope of the adaptation and that the term ?adaptive design? should be included in the trial title or at least in the brief summary or design sections.Electronic supplementary material: The online version of this article (doi:10.1186/s13063-016-1273-9) contains supplementary material, which is available to authorized users. äAdaptive designs undertaken in clinical research: a review of register(epmc).pdf DeepDyve Pubget Overpricing