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10.1016/j.molcel.2016.02.024 http://scihub22266oqcxt.onion/10.1016/j.molcel.2016.02.024 C4799497!4799497 !26990989     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26990989 &cmd=llinks): Failed to open stream: HTTP request failed! 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SON and Its Alternatively Spliced Isoforms Control MLL Complex-Mediated H3K4me3 and Transcription of Leukemia-Associated Genes |pdf=|usr=}}{{26990989 }} gab.com Text SON and Its Alternatively Spliced Isoforms Control MLL Complex-Mediated H3K4me3 and Transcription of Leukemia-Associated Genes JO: Mol Cell http://www.kidney.de/pget.php?&tw=1&pmid=26990989 #FOAvip Dysregulation of MLL complex-mediated histone methylation plays a pivotal role in gene expression associated with diseases, but little is known about cellular factors modulating MLL complex activity. Here, we report that SON, previously known as an RNA splicing factor, controls MLL complex-mediated transcriptional initiation. SON binds to DNA near transcription start sites, interacts with menin, and inhibits MLL complex assembly, resulting in decreased H3K4me3 and transcriptional repression. Importantly, alternatively spliced short isoforms of SON are markedly upregulated in acute myeloid leukemia. The short isoforms compete with full-length SON for chromatin occupancy but lack the menin-binding ability, thereby antagonizing full-length SON function in transcriptional repression while not impairing full-length SON-mediated RNA splicing. Furthermore, overexpression of a short isoform of SON enhances replating potential of hematopoietic progenitors. Our findings define SON as a fine-tuner of the MLL-menin interaction and reveal short SON overexpression as a marker indicating aberrant transcriptional initiation in leukemia. Twit Text FOAVip SON and Its Alternatively Spliced Isoforms Control MLL Complex-Mediated H3K4me3 and Transcription of Leukemia-Associated Genes ????Mol Cell http://www.kidney.de/pget.php?&tw=1&pmid=26990989 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26990989 #FOAvip English Wikipedia <ref>{{Cite pmid|26990989 }}</ref> SON and Its Alternatively Spliced Isoforms Control MLL Complex-Mediated H3K4me3 and Transcription of Leukemia-Associated Genes #MMPMID26990989 Kim JH ; Baddoo MC ; Park EY ; Stone JK ; Park H ; Butler TW ; Huang G ; Yan X ; Pauli-Behn F ; Myers RM ; Tan M ; Flemington EK ; Lim ST ; Ahn EY Mol Cell 2016[Mar]; 61 (6 ): 859-73 PMID26990989 show ga Dysregulation of MLL complex-mediated histone methylation plays a pivotal role in gene expression associated with diseases, but little is known about cellular factors modulating MLL complex activity. Here, we report that SON, previously known as an RNA splicing factor, controls MLL complex-mediated transcriptional initiation. SON binds to DNA near transcription start sites, interacts with menin, and inhibits MLL complex assembly, resulting in decreased H3K4me3 and transcriptional repression. Importantly, alternatively spliced short isoforms of SON are markedly upregulated in acute myeloid leukemia. The short isoforms compete with full-length SON for chromatin occupancy but lack the menin-binding ability, thereby antagonizing full-length SON function in transcriptional repression while not impairing full-length SON-mediated RNA splicing. Furthermore, overexpression of a short isoform of SON enhances replating potential of hematopoietic progenitors. Our findings define SON as a fine-tuner of the MLL-menin interaction and reveal short SON overexpression as a marker indicating aberrant transcriptional initiation in leukemia. |*Transcription, Genetic [MESH] |Alternative Splicing/genetics [MESH] |Cell Line, Tumor [MESH] |Chromatin/genetics [MESH] |DNA-Binding Proteins/biosynthesis/*genetics [MESH] |Gene Expression Regulation, Leukemic [MESH] |Histone-Lysine N-Methyltransferase/*biosynthesis/genetics [MESH] |Humans [MESH] |Leukemia, Myeloid, Acute/*genetics/pathology [MESH] |Methylation [MESH] |Minor Histocompatibility Antigens [MESH] |Myeloid-Lymphoid Leukemia Protein/*biosynthesis/genetics [MESH] |Protein Binding [MESH] |Protein Isoforms/genetics [MESH]SON and Its Alternatively Spliced Isoforms Control MLL Complex-Mediate(epmc).pdf DeepDyve Pubget Overpricing