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10.1016/j.it.2012.07.006

http://scihub22266oqcxt.onion/10.1016/j.it.2012.07.006
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C4799496!4799496!22959641
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suck abstract from ncbi


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pmid22959641      Trends+Immunol 2012 ; 33 (12): 598-606
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  • Cytokine-induced cytokine production by conventional and innate lymphoid cells #MMPMID22959641
  • Guo L; Junttila IS; Paul WE
  • Trends Immunol 2012[Dec]; 33 (12): 598-606 PMID22959641show ga
  • Innate immune and differentiated T cells produce signature cytokines in response to cytokine stimulation. Optimal production requires stimulation by an NF-?B inducer, most commonly an interleukin (IL)-1 family member, and a STAT activator. Usually, there is linkage between the IL-1 family member, the activated STAT and the cytokines produced: IFN? producers respond to the IL-1 family member, IL-18 and IL-12, a STAT4 activator; IL-13 producers respond to IL-33 (although for ILC2 cells this may be replaced by IL-25) and STAT5 activators; for cells producing IL-17A or IL-22, the combination is IL-1 and a STAT3 inducer. Cytokine-induced cytokine production may have broad significance in orchestrating innate responses to distinct infectious agents and in maintaining inflammatory responses after elimination of the inciting antigen.
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