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10.1038/ncomms11036 http://scihub22266oqcxt.onion/10.1038/ncomms11036 C4799373!4799373!26980715     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun 2016 ; 7 (ä): ä Nephropedia Template TP {{tp|p=26980715|t=2016. Cellular forces and matrix assembly coordinate fibrous tissue repair |pdf=|usr=}}{{26980715}} gab.com Text Cellular forces and matrix assembly coordinate fibrous tissue repair JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=26980715 #FOAvip Planar in vitro models have been invaluable tools to identify the mechanical basis of wound closure. Although these models may recapitulate closure dynamics of epithelial cell sheets, they fail to capture how a wounded fibrous tissue rebuilds its 3D architecture. Here we develop a 3D biomimetic model for soft tissue repair and demonstrate that fibroblasts ensconced in a collagen matrix rapidly close microsurgically induced defects within 24?h. Traction force microscopy and time-lapse imaging reveal that closure of gaps begins with contractility-mediated whole-tissue deformations. Subsequently, tangentially migrating fibroblasts along the wound edge tow and assemble a progressively thickening fibronectin template inside the gap that provide the substrate for cells to complete closure. Unlike previously reported mechanisms based on lamellipodial protrusions and purse-string contraction, our data reveal a mode of stromal closure in which coordination of tissue-scale deformations, matrix assembly and cell migration act together to restore 3D tissue architecture. Twit Text FOAVip Cellular forces and matrix assembly coordinate fibrous tissue repair ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=26980715 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26980715 #FOAvip English Wikipedia <ref>{{Cite pmid|26980715}}</ref> Cellular forces and matrix assembly coordinate fibrous tissue repair #MMPMID26980715 Sakar MS; Eyckmans J; Pieters R; Eberli D; Nelson BJ; Chen CS Nat Commun 2016[]; 7 (ä): ä PMID26980715show ga Planar in vitro models have been invaluable tools to identify the mechanical basis of wound closure. Although these models may recapitulate closure dynamics of epithelial cell sheets, they fail to capture how a wounded fibrous tissue rebuilds its 3D architecture. Here we develop a 3D biomimetic model for soft tissue repair and demonstrate that fibroblasts ensconced in a collagen matrix rapidly close microsurgically induced defects within 24?h. Traction force microscopy and time-lapse imaging reveal that closure of gaps begins with contractility-mediated whole-tissue deformations. Subsequently, tangentially migrating fibroblasts along the wound edge tow and assemble a progressively thickening fibronectin template inside the gap that provide the substrate for cells to complete closure. Unlike previously reported mechanisms based on lamellipodial protrusions and purse-string contraction, our data reveal a mode of stromal closure in which coordination of tissue-scale deformations, matrix assembly and cell migration act together to restore 3D tissue architecture. äCellular forces and matrix assembly coordinate fibrous tissue repair (epmc).pdf DeepDyve Pubget Overpricing