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10.1063/1.4944057 http://scihub22266oqcxt.onion/10.1063/1.4944057 C4798995!4798995!27042246     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Biomicrofluidics 2016 ; 10 (2): ä Nephropedia Template TP {{tp|p=27042246|t=2016. Microfluidic cell fragmentation for mechanical phenotyping of cancer cells |pdf=|usr=}}{{27042246}} gab.com Text Microfluidic cell fragmentation for mechanical phenotyping of cancer cells JO: Biomicrofluidics http://www.kidney.de/pget.php?&tw=1&pmid=27042246 #FOAvip Circulating tumor cells (CTCs) shed from the primary tumor undergo significant fragmentation in the microvasculature, and very few escape to instigate metastases. Inspired by this in vivo behavior of CTCs, we report a microfluidic method to phenotype cancer cells based on their ability to arrest and fragment at a micropillar-based bifurcation. We find that in addition to cancer cell size, mechanical properties determine fragmentability. We observe that highly metastatic prostate cancer cells are more resistant to fragmentation than weakly metastatic cells, providing the first indication that metastatic CTCs can escape rupture and potentially initiate secondary tumors. Our method may thus be useful in identifying phenotypes that succumb to or escape mechanical trauma in microcirculation. Twit Text FOAVip Microfluidic cell fragmentation for mechanical phenotyping of cancer cells ????Biomicrofluidics http://www.kidney.de/pget.php?&tw=1&pmid=27042246 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27042246 #FOAvip English Wikipedia <ref>{{Cite pmid|27042246}}</ref> Microfluidic cell fragmentation for mechanical phenotyping of cancer cells #MMPMID27042246 Kamyabi N; Vanapalli SA Biomicrofluidics 2016[Mar]; 10 (2): ä PMID27042246show ga Circulating tumor cells (CTCs) shed from the primary tumor undergo significant fragmentation in the microvasculature, and very few escape to instigate metastases. Inspired by this in vivo behavior of CTCs, we report a microfluidic method to phenotype cancer cells based on their ability to arrest and fragment at a micropillar-based bifurcation. We find that in addition to cancer cell size, mechanical properties determine fragmentability. We observe that highly metastatic prostate cancer cells are more resistant to fragmentation than weakly metastatic cells, providing the first indication that metastatic CTCs can escape rupture and potentially initiate secondary tumors. Our method may thus be useful in identifying phenotypes that succumb to or escape mechanical trauma in microcirculation. äMicrofluidic cell fragmentation for mechanical phenotyping of cancer c(epmc).pdf DeepDyve Pubget Overpricing