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2016 ; 5
(1
): 51-64
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The Second Brain: Is the Gut Microbiota a Link Between Obesity and Central
Nervous System Disorders?
#MMPMID26865085
Ochoa-Repáraz J
; Kasper LH
Curr Obes Rep
2016[Mar]; 5
(1
): 51-64
PMID26865085
show ga
The gut-brain axis is a bi-directional integrated system composed by immune,
endocrine, and neuronal components by which the gap between the gut microbiota
and the brain is significantly impacted. An increasing number of different gut
microbial species are now postulated to regulate brain function in health and
disease. The westernized diet is hypothesized to be the cause of the current
obesity levels in many countries, a major socio-economical health problem.
Experimental and epidemiological evidence suggest that the gut microbiota is
responsible for significant immunologic, neuronal, and endocrine changes that
lead to obesity. We hypothesize that the gut microbiota, and changes associated
with diet, affect the gut-brain axis and may possibly contribute to the
development of mental illness. In this review, we discuss the links between diet,
gut dysbiosis, obesity, and immunologic and neurologic diseases that impact brain
function and behavior.
|*Gastrointestinal Microbiome
[MESH]
|Animals
[MESH]
|Brain/physiology
[MESH]
|Central Nervous System Diseases/complications/microbiology
[MESH]