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10.1016/j.heares.2015.10.010 http://scihub22266oqcxt.onion/10.1016/j.heares.2015.10.010 C4798880!4798880 !26520584     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26520584 &cmd=llinks): Failed to open stream: HTTP request failed! 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Immune defense is the primary function associated with the differentially expressed genes in the cochlea following acoustic trauma |pdf=|usr=}}{{26520584 }} gab.com Text Immune defense is the primary function associated with the differentially expressed genes in the cochlea following acoustic trauma JO: Hear Res http://www.kidney.de/pget.php?&tw=1&pmid=26520584 #FOAvip Our previous RNA-sequencing analysis of the rat cochlear genes identified multiple biological processes and molecular pathways in the cochlear response to acoustic overstimulation. However, the biological processes and molecular pathways that are common to other species have not been documented. The identification of these common stress processes is pivotal for a better understanding of the essential response of the cochlea to acoustic injury. Here, we compared the RNA-sequencing data collected from mice and rats that sustained a similar, but not identical, acoustic injury. The transcriptome analysis of cochlear genes identified the differentially expressed genes in the mouse and rat samples. Bioinformatics analysis revealed a marked similarity in the changes in the biological processes between the two species, although the differentially expressed genes did not overlap well. The common processes associated with the differentially expressed genes are primarily associated with immunity and inflammation, which include the immune response, response to wounding, the defense response, chemotaxis and inflammatory responses. Moreover, analysis of the molecular pathways showed considerable overlap between the two species. The common pathways include cytokine-cytokine receptor interactions, the chemokine signaling pathway, the Toll-like receptor signaling pathway, and the NOD-like receptor signaling pathway. Further analysis of the transcriptional regulators revealed common upstream regulators of the differentially expressed genes, and these upstream regulators are also functionally related to the immune and inflammatory responses. These results suggest that the immune and inflammatory responses are the essential responses to acoustic overstimulation in the cochlea. Twit Text FOAVip Immune defense is the primary function associated with the differentially expressed genes in the cochlea following acoustic trauma ????Hear Res http://www.kidney.de/pget.php?&tw=1&pmid=26520584 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26520584 #FOAvip English Wikipedia <ref>{{Cite pmid|26520584 }}</ref> Immune defense is the primary function associated with the differentially expressed genes in the cochlea following acoustic trauma #MMPMID26520584 Yang S ; Cai Q ; Vethanayagam RR ; Wang J ; Yang W ; Hu BH Hear Res 2016[Mar]; 333 (ä): 283-294 PMID26520584 show ga Our previous RNA-sequencing analysis of the rat cochlear genes identified multiple biological processes and molecular pathways in the cochlear response to acoustic overstimulation. However, the biological processes and molecular pathways that are common to other species have not been documented. The identification of these common stress processes is pivotal for a better understanding of the essential response of the cochlea to acoustic injury. Here, we compared the RNA-sequencing data collected from mice and rats that sustained a similar, but not identical, acoustic injury. The transcriptome analysis of cochlear genes identified the differentially expressed genes in the mouse and rat samples. Bioinformatics analysis revealed a marked similarity in the changes in the biological processes between the two species, although the differentially expressed genes did not overlap well. The common processes associated with the differentially expressed genes are primarily associated with immunity and inflammation, which include the immune response, response to wounding, the defense response, chemotaxis and inflammatory responses. Moreover, analysis of the molecular pathways showed considerable overlap between the two species. The common pathways include cytokine-cytokine receptor interactions, the chemokine signaling pathway, the Toll-like receptor signaling pathway, and the NOD-like receptor signaling pathway. Further analysis of the transcriptional regulators revealed common upstream regulators of the differentially expressed genes, and these upstream regulators are also functionally related to the immune and inflammatory responses. These results suggest that the immune and inflammatory responses are the essential responses to acoustic overstimulation in the cochlea. |*Gene Expression Regulation [MESH] |Animals [MESH] |Cochlea/*immunology/physiopathology [MESH] |Computational Biology [MESH] |Databases, Genetic [MESH] |Disease Models, Animal [MESH] |Female [MESH] |Gene Expression Profiling/methods [MESH] |Hearing Loss, Noise-Induced/*genetics/*immunology/physiopathology [MESH] |Male [MESH] |Mice, Inbred CBA [MESH] |Noise/*adverse effects [MESH] |RNA, Messenger/genetics/metabolism [MESH] |Rats, Sprague-Dawley [MESH] |Sequence Analysis, RNA [MESH]Immune defense is the primary function associated with the differentia(epmc).pdf DeepDyve Pubget Overpricing