Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1016/j.febslet.2009.04.039 http://scihub22266oqcxt.onion/10.1016/j.febslet.2009.04.039 C4798241!4798241!19416727     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       FEBS+Lett 2009 ; 583 (12): 1933-8 Nephropedia Template TP {{tp|p=19416727|t=2009. p38 mitogen-activated protein kinase inhibits tristetraprolin-directed decay of the mRNA of the anti-inflammatory cytokine interleukin-10 |pdf=|usr=}}{{19416727}} gab.com Text p38 mitogen-activated protein kinase inhibits tristetraprolin-directed decay of the mRNA of the anti-inflammatory cytokine interleukin-10 JO: FEBS Lett http://www.kidney.de/pget.php?&tw=1&pmid=19416727 #FOAvip p38 mitogen-activated protein kinase (MAPK) stabilises mRNAs of pro-inflammatory mediators by inhibiting AU-rich element-mediated decay. We show that in bone marrow-derived macrophages (BMDM) tumour necrosis factor (TNF) mRNA is stabilised by inactivation of the AU-rich element-binding protein tristetraprolin (TTP) by the p38 MAPK pathway. We show that this mechanism is not limited to TNF mRNA and that p38 MAPK also inhibits TTP-directed decay of interleukin (IL)-10 mRNA. Lipopolysaccharide-induced IL-10 mRNA and protein expression was increased in TTP?/? compared with wild-type BMDM. We also provide evidence that TTP directly targets IL-10 mRNA by binding to its 3?-untranslated region. We found that p38 MAPK activation also prevents TTP-directed decay of cyclooxygenase-2, IL-6, and IL-1? mRNAs. However, despite destabilisation of IL-6 mRNA by TTP, IL-6 mRNA and protein expression was reduced in TTP?/? BMDM and IL-12p40 mRNA and protein expression was also reduced in TTP?/? BMDM. Neutralisation of IL-10 in lipopolysaccharide-treated BMDM with an anti-IL-10 antibody rescued the inhibition of IL-6 and IL-12p40 protein in TTP?/? cells. Thus the p38 MAPK pathway acting in conjunction with TTP regulates the stability and expression of not only pro-inflammatory mRNAs but also the mRNA of the anti-inflammatory cytokine, IL-10. Twit Text FOAVip p38 mitogen-activated protein kinase inhibits tristetraprolin-directed decay of the mRNA of the anti-inflammatory cytokine interleukin-10 ????FEBS Lett http://www.kidney.de/pget.php?&tw=1&pmid=19416727 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=19416727 #FOAvip English Wikipedia <ref>{{Cite pmid|19416727}}</ref> p38 mitogen-activated protein kinase inhibits tristetraprolin-directed decay of the mRNA of the anti-inflammatory cytokine interleukin-10 #MMPMID19416727 Tudor C; Hitti E; Rawlinson L; Blackshear PJ; Gaestel M; Clark AR; Saklatvala J; Dean JL FEBS Lett 2009[Jun]; 583 (12): 1933-8 PMID19416727show ga p38 mitogen-activated protein kinase (MAPK) stabilises mRNAs of pro-inflammatory mediators by inhibiting AU-rich element-mediated decay. We show that in bone marrow-derived macrophages (BMDM) tumour necrosis factor (TNF) mRNA is stabilised by inactivation of the AU-rich element-binding protein tristetraprolin (TTP) by the p38 MAPK pathway. We show that this mechanism is not limited to TNF mRNA and that p38 MAPK also inhibits TTP-directed decay of interleukin (IL)-10 mRNA. Lipopolysaccharide-induced IL-10 mRNA and protein expression was increased in TTP?/? compared with wild-type BMDM. We also provide evidence that TTP directly targets IL-10 mRNA by binding to its 3?-untranslated region. We found that p38 MAPK activation also prevents TTP-directed decay of cyclooxygenase-2, IL-6, and IL-1? mRNAs. However, despite destabilisation of IL-6 mRNA by TTP, IL-6 mRNA and protein expression was reduced in TTP?/? BMDM and IL-12p40 mRNA and protein expression was also reduced in TTP?/? BMDM. Neutralisation of IL-10 in lipopolysaccharide-treated BMDM with an anti-IL-10 antibody rescued the inhibition of IL-6 and IL-12p40 protein in TTP?/? cells. Thus the p38 MAPK pathway acting in conjunction with TTP regulates the stability and expression of not only pro-inflammatory mRNAs but also the mRNA of the anti-inflammatory cytokine, IL-10. äp38 mitogen-activated protein kinase inhibits tristetraprolin-directed(epmc).pdf DeepDyve Pubget Overpricing