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2014 ; 129
(6
): 916-31
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Animal models of sports-related head injury: bridging the gap between
pre-clinical research and clinical reality
#MMPMID24673291
Angoa-Pérez M
; Kane MJ
; Briggs DI
; Herrera-Mundo N
; Viano DC
; Kuhn DM
J Neurochem
2014[Jun]; 129
(6
): 916-31
PMID24673291
show ga
Sports-related head impact and injury has become a very highly contentious public
health and medico-legal issue. Near-daily news accounts describe the travails of
concussed athletes as they struggle with depression, sleep disorders, mood
swings, and cognitive problems. Some of these individuals have developed chronic
traumatic encephalopathy, a progressive and debilitating neurodegenerative
disorder. Animal models have always been an integral part of the study of
traumatic brain injury in humans but, historically, they have concentrated on
acute, severe brain injuries. This review will describe a small number of new and
emerging animal models of sports-related head injury that have the potential to
increase our understanding of how multiple mild head impacts, starting in
adolescence, can have serious psychiatric, cognitive and histopathological
outcomes much later in life. Sports-related head injury (SRHI) has emerged as a
significant public health issue as athletes can develop psychiatric and
neurodegenerative disorders later in life. Animal models have always been an
integral part of the study of human TBI but few existing methods are valid for
studying SRHI. In this review, we propose criteria for effective animal models of
SRHI. Movement of the head upon impact is judged to be of primary importance in
leading to concussion and persistent CNS dysfunction.