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10.1159/000373949 http://scihub22266oqcxt.onion/10.1159/000373949 C4797942!4797942 !25721445     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25721445 &cmd=llinks): Failed to open stream: HTTP request failed! 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Phosphatidylinositol-3,4,5-triphosphate and cellular signaling: implications for obesity and diabetes |pdf=|usr=}}{{25721445 }} gab.com Text Phosphatidylinositol-3,4,5-triphosphate and cellular signaling: implications for obesity and diabetes JO: Cell Physiol Biochem http://www.kidney.de/pget.php?&tw=1&pmid=25721445 #FOAvip Phosphatidylinositol-3,4,5-triphosphate (PtdIns(3,4,5)P?) is one of the most important phosphoinositides and is capable of activating a wide range of proteins through its interaction with their specific binding domains. Localization and activation of these effector proteins regulate a number of cellular functions, including cell survival, proliferation, cytoskeletal rearrangement, intracellular vesicle trafficking, and cell metabolism. Phosphoinositides have been investigated as an important agonist-dependent second messenger in the regulation of diverse physiological events depending upon the phosphorylation status of their inositol group. Dysregulation in formation as well as metabolism of phosphoinositides is associated with various pathophysiological disorders such as inflammation, allergy, cardiovascular diseases, cancer, and metabolic diseases. Recent studies have demonstrated that the impaired metabolism of PtdIns(3,4,5)P? is a prime mediator of insulin resistance associated with various metabolic diseases including obesity and diabetes. This review examines the current status of the role of PtdIns(3,4,5)P? signaling in the regulation of various cellular functions and the implications of dysregulated PtdIns(3,4,5)P? signaling in obesity, diabetes, and their associated complications. Twit Text FOAVip Phosphatidylinositol-3,4,5-triphosphate and cellular signaling: implications for obesity and diabetes ????Cell Physiol Biochem http://www.kidney.de/pget.php?&tw=1&pmid=25721445 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25721445 #FOAvip English Wikipedia <ref>{{Cite pmid|25721445 }}</ref> Phosphatidylinositol-3,4,5-triphosphate and cellular signaling: implications for obesity and diabetes #MMPMID25721445 Manna P ; Jain SK Cell Physiol Biochem 2015[]; 35 (4 ): 1253-75 PMID25721445 show ga Phosphatidylinositol-3,4,5-triphosphate (PtdIns(3,4,5)P?) is one of the most important phosphoinositides and is capable of activating a wide range of proteins through its interaction with their specific binding domains. Localization and activation of these effector proteins regulate a number of cellular functions, including cell survival, proliferation, cytoskeletal rearrangement, intracellular vesicle trafficking, and cell metabolism. Phosphoinositides have been investigated as an important agonist-dependent second messenger in the regulation of diverse physiological events depending upon the phosphorylation status of their inositol group. Dysregulation in formation as well as metabolism of phosphoinositides is associated with various pathophysiological disorders such as inflammation, allergy, cardiovascular diseases, cancer, and metabolic diseases. Recent studies have demonstrated that the impaired metabolism of PtdIns(3,4,5)P? is a prime mediator of insulin resistance associated with various metabolic diseases including obesity and diabetes. This review examines the current status of the role of PtdIns(3,4,5)P? signaling in the regulation of various cellular functions and the implications of dysregulated PtdIns(3,4,5)P? signaling in obesity, diabetes, and their associated complications. |*Signal Transduction [MESH] |Cardiovascular Diseases/metabolism/pathology [MESH] |Diabetes Mellitus, Type 2/metabolism/*pathology [MESH] |Humans [MESH] |Insulin Resistance [MESH] |Obesity/metabolism/*pathology [MESH] |PTEN Phosphohydrolase/metabolism [MESH] |Phosphatidylinositol 3-Kinases/metabolism [MESH]Phosphatidylinositol-3,4,5-triphosphate and cellular signaling: implic(epmc).pdf DeepDyve Pubget Overpricing