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10.1186/s12943-016-0509-3 http://scihub22266oqcxt.onion/10.1186/s12943-016-0509-3 C4797362!4797362!26988232     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Mol+Cancer 2016 ; 15 (ä): ä Nephropedia Template TP {{tp|p=26988232|t=2016. Hedgehog signaling: modulation of cancer properies and tumor mircroenvironment |pdf=|usr=}}{{26988232}} gab.com Text Hedgehog signaling: modulation of cancer properies and tumor mircroenvironment JO: Mol Cancer http://www.kidney.de/pget.php?&tw=1&pmid=26988232 #FOAvip Cancer poses a serious health problem in society and is increasingly surpassing cardiovascular disease as the leading cause of mortality in the United States. Current therapeutic strategies for cancer are extreme and harsh to patients and often have limited success; the danger of cancer is intensified as it metastasizes to secondary locations such as lung, bone, and liver, posing a dire threat to patient treatment and survival. Hedgehog signaling is an important pathway for normal development. Initially identified in Drosophila, the vertebrate and mammalian equivalent of the pathway has been studied extensively for its role in cancer development and progression. As this pathway regulates key target genes involved in development, its action also allows for the modulation of the microenvironment to prepare a tumor-suitable niche by manipulating tumor cell growth, differentiation, and immune regulation, thus creating an enabling environment for progression and metastasis. In this review, we will summarize recent scientific discoveries reporting the impact of the Hedgehog signaling pathway on the tumor initiation process and metastatic cascade, shedding light on the ability of the tumor to take over a mechanism crucially intended for development and normal function. Twit Text FOAVip Hedgehog signaling: modulation of cancer properies and tumor mircroenvironment ????Mol Cancer http://www.kidney.de/pget.php?&tw=1&pmid=26988232 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26988232 #FOAvip English Wikipedia <ref>{{Cite pmid|26988232}}</ref> Hedgehog signaling: modulation of cancer properies and tumor mircroenvironment #MMPMID26988232 Hanna A; Shevde LA Mol Cancer 2016[]; 15 (ä): ä PMID26988232show ga Cancer poses a serious health problem in society and is increasingly surpassing cardiovascular disease as the leading cause of mortality in the United States. Current therapeutic strategies for cancer are extreme and harsh to patients and often have limited success; the danger of cancer is intensified as it metastasizes to secondary locations such as lung, bone, and liver, posing a dire threat to patient treatment and survival. Hedgehog signaling is an important pathway for normal development. Initially identified in Drosophila, the vertebrate and mammalian equivalent of the pathway has been studied extensively for its role in cancer development and progression. As this pathway regulates key target genes involved in development, its action also allows for the modulation of the microenvironment to prepare a tumor-suitable niche by manipulating tumor cell growth, differentiation, and immune regulation, thus creating an enabling environment for progression and metastasis. In this review, we will summarize recent scientific discoveries reporting the impact of the Hedgehog signaling pathway on the tumor initiation process and metastatic cascade, shedding light on the ability of the tumor to take over a mechanism crucially intended for development and normal function. äHedgehog signaling: modulation of cancer properies and tumor mircroenv(epmc).pdf DeepDyve Pubget Overpricing