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10.1038/ng.3406 http://scihub22266oqcxt.onion/10.1038/ng.3406 C4797329!4797329!26414676     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Genet 2015 ; 47 (11): 1236-41 Nephropedia Template TP {{tp|p=26414676|t=2015. An Atlas of Genetic Correlations across Human Diseases and Traits |pdf=|usr=}}{{26414676}} gab.com Text An Atlas of Genetic Correlations across Human Diseases and Traits JO: Nat Genet http://www.kidney.de/pget.php?&tw=1&pmid=26414676 #FOAvip Identifying genetic correlations between complex traits and diseases can provide useful etiological insights and help prioritize likely causal relationships. The major challenges preventing estimation of genetic correlation from genome-wide association study (GWAS) data with current methods are the lack of availability of individual genotype data and widespread sample overlap among meta-analyses. We circumvent these difficulties by introducing a technique ? cross-trait LD Score regression ? for estimating genetic correlation that requires only GWAS summary statistics and is not biased by sample overlap. We use this method to estimate 276 genetic correlations among 24 traits. The results include genetic correlations between anorexia nervosa and schizophrenia, anorexia and obesity and associations between educational attainment and several diseases. These results highlight the power of genome-wide analyses, since there currently are no significantly associated SNPs for anorexia nervosa and only three for educational attainment. Twit Text FOAVip An Atlas of Genetic Correlations across Human Diseases and Traits ????Nat Genet http://www.kidney.de/pget.php?&tw=1&pmid=26414676 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26414676 #FOAvip English Wikipedia <ref>{{Cite pmid|26414676}}</ref> An Atlas of Genetic Correlations across Human Diseases and Traits #MMPMID26414676 Bulik-Sullivan B; Finucane HK; Anttila V; Gusev A; Day FR; Loh PR; Duncan L; Perry JR; Patterson N; Robinson EB; Daly MJ; Price AL; Neale BM Nat Genet 2015[Nov]; 47 (11): 1236-41 PMID26414676show ga Identifying genetic correlations between complex traits and diseases can provide useful etiological insights and help prioritize likely causal relationships. The major challenges preventing estimation of genetic correlation from genome-wide association study (GWAS) data with current methods are the lack of availability of individual genotype data and widespread sample overlap among meta-analyses. We circumvent these difficulties by introducing a technique ? cross-trait LD Score regression ? for estimating genetic correlation that requires only GWAS summary statistics and is not biased by sample overlap. We use this method to estimate 276 genetic correlations among 24 traits. The results include genetic correlations between anorexia nervosa and schizophrenia, anorexia and obesity and associations between educational attainment and several diseases. These results highlight the power of genome-wide analyses, since there currently are no significantly associated SNPs for anorexia nervosa and only three for educational attainment. äAn Atlas of Genetic Correlations across Human Diseases and Traits (epmc).pdf DeepDyve Pubget Overpricing