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10.1093/nar/gkw079

http://scihub22266oqcxt.onion/10.1093/nar/gkw079
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C4797304!4797304!26883636
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suck abstract from ncbi

pmid26883636      Nucleic+Acids+Res 2016 ; 44 (5): 1989-2006
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  • G-quadruplexes and helicases #MMPMID26883636
  • Mendoza O; Bourdoncle A; Boulé JB; Brosh RM; Mergny JL
  • Nucleic Acids Res 2016[Mar]; 44 (5): 1989-2006 PMID26883636show ga
  • Guanine-rich DNA strands can fold in vitro into non-canonical DNA structures called G-quadruplexes. These structures may be very stable under physiological conditions. Evidence suggests that G-quadruplex structures may act as ?knots? within genomic DNA, and it has been hypothesized that proteins may have evolved to remove these structures. The first indication of how G-quadruplex structures could be unfolded enzymatically came in the late 1990s with reports that some well-known duplex DNA helicases resolved these structures in vitro. Since then, the number of studies reporting G-quadruplex DNA unfolding by helicase enzymes has rapidly increased. The present review aims to present a general overview of the helicase/G-quadruplex field.
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