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10.1093/nar/gkw035 http://scihub22266oqcxt.onion/10.1093/nar/gkw035 C4797294!4797294!26857546     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nucleic+Acids+Res 2016 ; 44 (5): 2266-73 Nephropedia Template TP {{tp|p=26857546|t=2016. Molecular sled sequences are common in mammalian proteins |pdf=|usr=}}{{26857546}} gab.com Text Molecular sled sequences are common in mammalian proteins JO: Nucleic Acids Res http://www.kidney.de/pget.php?&tw=1&pmid=26857546 #FOAvip Recent work revealed a new class of molecular machines called molecular sleds, which are small basic molecules that bind and slide along DNA with the ability to carry cargo along DNA. Here, we performed biochemical and single-molecule flow stretching assays to investigate the basis of sliding activity in molecular sleds. In particular, we identified the functional core of pVIc, the first molecular sled characterized; peptide functional groups that control sliding activity; and propose a model for the sliding activity of molecular sleds. We also observed widespread DNA binding and sliding activity among basic polypeptide sequences that implicate mammalian nuclear localization sequences and many cell penetrating peptides as molecular sleds. These basic protein motifs exhibit weak but physiologically relevant sequence-nonspecific DNA affinity. Our findings indicate that many mammalian proteins contain molecular sled sequences and suggest the possibility that substantial undiscovered sliding activity exists among nuclear mammalian proteins. Twit Text FOAVip Molecular sled sequences are common in mammalian proteins ????Nucleic Acids Res http://www.kidney.de/pget.php?&tw=1&pmid=26857546 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26857546 #FOAvip English Wikipedia <ref>{{Cite pmid|26857546}}</ref> Molecular sled sequences are common in mammalian proteins #MMPMID26857546 Xiong K; Blainey PC Nucleic Acids Res 2016[Mar]; 44 (5): 2266-73 PMID26857546show ga Recent work revealed a new class of molecular machines called molecular sleds, which are small basic molecules that bind and slide along DNA with the ability to carry cargo along DNA. Here, we performed biochemical and single-molecule flow stretching assays to investigate the basis of sliding activity in molecular sleds. In particular, we identified the functional core of pVIc, the first molecular sled characterized; peptide functional groups that control sliding activity; and propose a model for the sliding activity of molecular sleds. We also observed widespread DNA binding and sliding activity among basic polypeptide sequences that implicate mammalian nuclear localization sequences and many cell penetrating peptides as molecular sleds. These basic protein motifs exhibit weak but physiologically relevant sequence-nonspecific DNA affinity. Our findings indicate that many mammalian proteins contain molecular sled sequences and suggest the possibility that substantial undiscovered sliding activity exists among nuclear mammalian proteins. äMolecular sled sequences are common in mammalian proteins (epmc).pdf DeepDyve Pubget Overpricing