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10.1093/nar/gkw017 http://scihub22266oqcxt.onion/10.1093/nar/gkw017 C4797289!4797289!26819413     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nucleic+Acids+Res 2016 ; 44 (5): 2378-92 Nephropedia Template TP {{tp|p=26819413|t=2016. LncRNA OIP5-AS1/cyrano sponges RNA-binding protein HuR |pdf=|usr=}}{{26819413}} gab.com Text LncRNA OIP5-AS1/cyrano sponges RNA-binding protein HuR JO: Nucleic Acids Res http://www.kidney.de/pget.php?&tw=1&pmid=26819413 #FOAvip The function of the vast majority of mammalian long noncoding (lnc) RNAs remains unknown. Here, analysis of a highly abundant mammalian lncRNA, OIP5-AS1, known as cyrano in zebrafish, revealed that OIP5-AS1 reduces cell proliferation. In human cervical carcinoma HeLa cells, the RNA-binding protein HuR, which enhances cell proliferation, associated with OIP5-AS1 and stabilized it. Tagging OIP5-AS1 with MS2 hairpins to identify associated microRNAs revealed that miR-424 interacted with OIP5-AS1 and competed with HuR for binding to OIP5-AS1. We further identified a ?sponge? function for OIP5-AS1, as high levels of OIP5-AS1 increased HuR-OIP5-AS1 complexes and prevented HuR interaction with target mRNAs, including those that encoded proliferative proteins, while conversely, lowering OIP5-AS1 increased the abundance of HuR complexes with target mRNAs. We propose that OIP5-AS1 serves as a sponge or a competing endogenous (ce)RNA for HuR, restricting its availability to HuR target mRNAs and thereby repressing HuR-elicited proliferative phenotypes. Twit Text FOAVip LncRNA OIP5-AS1/cyrano sponges RNA-binding protein HuR ????Nucleic Acids Res http://www.kidney.de/pget.php?&tw=1&pmid=26819413 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26819413 #FOAvip English Wikipedia <ref>{{Cite pmid|26819413}}</ref> LncRNA OIP5-AS1/cyrano sponges RNA-binding protein HuR #MMPMID26819413 Kim J; Abdelmohsen K; Yang X; De S; Grammatikakis I; Noh JH; Gorospe M Nucleic Acids Res 2016[Mar]; 44 (5): 2378-92 PMID26819413show ga The function of the vast majority of mammalian long noncoding (lnc) RNAs remains unknown. Here, analysis of a highly abundant mammalian lncRNA, OIP5-AS1, known as cyrano in zebrafish, revealed that OIP5-AS1 reduces cell proliferation. In human cervical carcinoma HeLa cells, the RNA-binding protein HuR, which enhances cell proliferation, associated with OIP5-AS1 and stabilized it. Tagging OIP5-AS1 with MS2 hairpins to identify associated microRNAs revealed that miR-424 interacted with OIP5-AS1 and competed with HuR for binding to OIP5-AS1. We further identified a ?sponge? function for OIP5-AS1, as high levels of OIP5-AS1 increased HuR-OIP5-AS1 complexes and prevented HuR interaction with target mRNAs, including those that encoded proliferative proteins, while conversely, lowering OIP5-AS1 increased the abundance of HuR complexes with target mRNAs. We propose that OIP5-AS1 serves as a sponge or a competing endogenous (ce)RNA for HuR, restricting its availability to HuR target mRNAs and thereby repressing HuR-elicited proliferative phenotypes. äLncRNA OIP5-AS1/cyrano sponges RNA-binding protein HuR (epmc).pdf DeepDyve Pubget Overpricing