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10.1016/j.neuron.2016.01.042 http://scihub22266oqcxt.onion/10.1016/j.neuron.2016.01.042 C4795969!4795969 !26924435     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26924435 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Neuron 2016 ; 89 (6 ): 1208-1222 Nephropedia Template TP {{tp|p=26924435 |t=2016. Down Syndrome Developmental Brain Transcriptome Reveals Defective Oligodendrocyte Differentiation and Myelination |pdf=|usr=}}{{26924435 }} gab.com Text Down Syndrome Developmental Brain Transcriptome Reveals Defective Oligodendrocyte Differentiation and Myelination JO: Neuron http://www.kidney.de/pget.php?&tw=1&pmid=26924435 #FOAvip Trisomy 21, or Down syndrome (DS), is the most common genetic cause of developmental delay and intellectual disability. To gain insight into the underlying molecular and cellular pathogenesis, we conducted a multi-region transcriptome analysis of DS and euploid control brains spanning from mid-fetal development to adulthood. We found genome-wide alterations in the expression of a large number of genes, many of which exhibited temporal and spatial specificity and were associated with distinct biological processes. In particular, we uncovered co-dysregulation of genes associated with oligodendrocyte differentiation and myelination that were validated via cross-species comparison to Ts65Dn trisomy mice. Furthermore, we show that hypomyelination present in Ts65Dn mice is in part due to cell-autonomous effects of trisomy on oligodendrocyte differentiation and results in slower neocortical action potential transmission. Together, these results identify defects in white matter development and function in DS, and they provide a transcriptional framework for further investigating DS neuropathogenesis. Twit Text FOAVip Down Syndrome Developmental Brain Transcriptome Reveals Defective Oligodendrocyte Differentiation and Myelination ????Neuron http://www.kidney.de/pget.php?&tw=1&pmid=26924435 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26924435 #FOAvip English Wikipedia <ref>{{Cite pmid|26924435 }}</ref> Down Syndrome Developmental Brain Transcriptome Reveals Defective Oligodendrocyte Differentiation and Myelination #MMPMID26924435 Olmos-Serrano JL ; Kang HJ ; Tyler WA ; Silbereis JC ; Cheng F ; Zhu Y ; Pletikos M ; Jankovic-Rapan L ; Cramer NP ; Galdzicki Z ; Goodliffe J ; Peters A ; Sethares C ; Delalle I ; Golden JA ; Haydar TF ; Sestan N Neuron 2016[Mar]; 89 (6 ): 1208-1222 PMID26924435 show ga Trisomy 21, or Down syndrome (DS), is the most common genetic cause of developmental delay and intellectual disability. To gain insight into the underlying molecular and cellular pathogenesis, we conducted a multi-region transcriptome analysis of DS and euploid control brains spanning from mid-fetal development to adulthood. We found genome-wide alterations in the expression of a large number of genes, many of which exhibited temporal and spatial specificity and were associated with distinct biological processes. In particular, we uncovered co-dysregulation of genes associated with oligodendrocyte differentiation and myelination that were validated via cross-species comparison to Ts65Dn trisomy mice. Furthermore, we show that hypomyelination present in Ts65Dn mice is in part due to cell-autonomous effects of trisomy on oligodendrocyte differentiation and results in slower neocortical action potential transmission. Together, these results identify defects in white matter development and function in DS, and they provide a transcriptional framework for further investigating DS neuropathogenesis. |*Brain/growth & development/metabolism/pathology [MESH] |Action Potentials/genetics [MESH] |Adolescent [MESH] |Adult [MESH] |Animals [MESH] |Cell Differentiation/*genetics/physiology [MESH] |Child [MESH] |Child, Preschool [MESH] |Chromosomes, Human, Pair 17/genetics [MESH] |Disease Models, Animal [MESH] |Down Syndrome/genetics/*pathology/physiopathology [MESH] |Female [MESH] |Gene Expression Profiling [MESH] |Gene Expression Regulation, Developmental/*genetics [MESH] |Humans [MESH] |Infant [MESH] |Infant, Newborn [MESH] |Male [MESH] |Mice [MESH] |Mice, Transgenic [MESH] |Mosaicism [MESH] |Myelin Basic Protein/genetics/metabolism [MESH] |Myelin Sheath/*metabolism/pathology/ultrastructure [MESH] |Neural Conduction/genetics [MESH] |Oligodendroglia/*pathology [MESH] |Postmortem Changes [MESH] |Trisomy/genetics [MESH] |White Matter/pathology/ultrastructure [MESH]Down Syndrome Developmental Brain Transcriptome Reveals Defective Olig(epmc).pdf DeepDyve Pubget Overpricing