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2016 ; 2016
(ä): ä Nephropedia Template TP
gab.com Text
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English Wikipedia
HistoneDB 2 0: a histone database with variants--an integrated resource to
explore histones and their variants
#MMPMID26989147
Draizen EJ
; Shaytan AK
; Marińo-Ramírez L
; Talbert PB
; Landsman D
; Panchenko AR
Database (Oxford)
2016[]; 2016
(ä): ä PMID26989147
show ga
Compaction of DNA into chromatin is a characteristic feature of eukaryotic
organisms. The core (H2A, H2B, H3, H4) and linker (H1) histone proteins are
responsible for this compaction through the formation of nucleosomes and higher
order chromatin aggregates. Moreover, histones are intricately involved in
chromatin functioning and provide a means for genome dynamic regulation through
specific histone variants and histone post-translational modifications.
'HistoneDB 2.0--with variants' is a comprehensive database of histone protein
sequences, classified by histone types and variants. All entries in the database
are supplemented by rich sequence and structural annotations with many
interactive tools to explore and compare sequences of different variants from
various organisms. The core of the database is a manually curated set of histone
sequences grouped into 30 different variant subsets with variant-specific
annotations. The curated set is supplemented by an automatically extracted set of
histone sequences from the non-redundant protein database using algorithms
trained on the curated set. The interactive web site supports various searching
strategies in both datasets: browsing of phylogenetic trees; on-demand generation
of multiple sequence alignments with feature annotations; classification of
histone-like sequences and browsing of the taxonomic diversity for every histone
variant. HistoneDB 2.0 is a resource for the interactive comparative analysis of
histone protein sequences and their implications for chromatin function. Database
URL: http://www.ncbi.nlm.nih.gov/projects/HistoneDB2.0.