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2016 ; 55
(4
): 607-14
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Towards prevention of autoantibody-positive rheumatoid arthritis: from lifestyle
modification to preventive treatment
#MMPMID26374913
Gerlag DM
; Norris JM
; Tak PP
Rheumatology (Oxford)
2016[Apr]; 55
(4
): 607-14
PMID26374913
show ga
Recent advances in research into the earliest phases of RA have provided
additional insights into the processes leading from the healthy to the diseased
state. These insights have opened the way for the development of preventive
strategies for RA, which represents a significant paradigm shift from treatment
to prevention and will have major implications for patients as well as society.
It would be a huge step forward if clinical signs and symptoms, disability,
impaired quality of life and the need for chronic immunosuppressive treatment
could be prevented. RA can be seen as a prototypic autoimmune disease, and
discoveries about the preclinical diseased state for RA could potentially
facilitate research into prevention of other immune-mediated inflammatory
diseases such as type 1 diabetes, SLE and multiple sclerosis. This review focuses
on the current knowledge of factors contributing to the development of RA and
discusses the opportunities for intervention.
|*Life Style
[MESH]
|Antirheumatic Agents/therapeutic use
[MESH]
|Arthritis, Rheumatoid/etiology/pathology/*prevention & control
[MESH]