Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1038/ni.3306 http://scihub22266oqcxt.onion/10.1038/ni.3306 C4795476!4795476!26681459     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26681459&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Immunol 2015 ; 17 (1): 26-33 Nephropedia Template TP {{tp|p=26681459|t=2015. Molecular control of activation and priming in macrophages |pdf=|usr=}}{{26681459}} gab.com Text Molecular control of activation and priming in macrophages JO: Nat Immunol http://www.kidney.de/pget.php?&tw=1&pmid=26681459 #FOAvip In tissues, macrophages are exposed to metabolic, homeostatic and immune-regulatory signals of local or systemic origin that influence their basal functions and responses to danger signals. Signal transduction pathways regulated by extracellular signals are coupled to distinct sets of broadly expressed stimulus-regulated transcription factors whose ability to elicit gene expression changes is influenced by the accessibility of their DNA binding sites in the macrophage genome. In turn, accessibility of macrophage-specific transcriptional regulatory elements (enhancers and promoters) is specified by transcription factors that determine the macrophage lineage or impose their tissue-specific properties. Here, we review recent findings that advance our understanding of mechanisms underlying priming and signal-dependent activation of macrophages, and discuss the impact of genetic variation on these processes. Twit Text FOAVip Molecular control of activation and priming in macrophages ????Nat Immunol http://www.kidney.de/pget.php?&tw=1&pmid=26681459 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26681459 #FOAvip English Wikipedia <ref>{{Cite pmid|26681459}}</ref> Molecular control of activation and priming in macrophages #MMPMID26681459 Glass CK; Natoli G Nat Immunol 2015[Dec]; 17 (1): 26-33 PMID26681459show ga In tissues, macrophages are exposed to metabolic, homeostatic and immune-regulatory signals of local or systemic origin that influence their basal functions and responses to danger signals. Signal transduction pathways regulated by extracellular signals are coupled to distinct sets of broadly expressed stimulus-regulated transcription factors whose ability to elicit gene expression changes is influenced by the accessibility of their DNA binding sites in the macrophage genome. In turn, accessibility of macrophage-specific transcriptional regulatory elements (enhancers and promoters) is specified by transcription factors that determine the macrophage lineage or impose their tissue-specific properties. Here, we review recent findings that advance our understanding of mechanisms underlying priming and signal-dependent activation of macrophages, and discuss the impact of genetic variation on these processes. äMolecular control of activation and priming in macrophages (epmc).pdf DeepDyve Pubget Overpricing