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10.1016/j.immuni.2016.02.016 http://scihub22266oqcxt.onion/10.1016/j.immuni.2016.02.016 C4794998!4794998!26982356     free     free     free       Immunity 2016 ; 44 (3): 492-504 Nephropedia Template TP {{tp|p=26982356|t=2016. Macrophages and iron metabolism |pdf=|usr=}}{{26982356}} gab.com Text Macrophages and iron metabolism JO: Immunity http://www.kidney.de/pget.php?&tw=1&pmid=26982356 #FOAvip Iron is a transition metal that due to its inherent ability to exchange electrons with a variety of molecules is essential to support life. In mammals, iron exists mostly in the form of heme, enclosed within an organic protoporphyrin ring and functioning primarily as a prosthetic group in proteins. Paradoxically, free iron also has the potential to become cytotoxic when electron exchange with oxygen is unrestricted and catalyzes the production of reactive oxygen species. These biological properties demand that iron metabolism is tightly regulated such that iron is available for core biological functions whilst preventing its cytotoxic effects. Macrophages play a central role in establishing this delicate balance. Here, we review the impact of macrophages on heme-iron metabolism and, reciprocally, how heme-iron modulates macrophage function. Twit Text FOAVip Macrophages and iron metabolism ????Immunity http://www.kidney.de/pget.php?&tw=1&pmid=26982356 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26982356 #FOAvip English Wikipedia <ref>{{Cite pmid|26982356}}</ref> Macrophages and iron metabolism #MMPMID26982356 Soares MP; Hamza I Immunity 2016[Mar]; 44 (3): 492-504 PMID26982356show ga Iron is a transition metal that due to its inherent ability to exchange electrons with a variety of molecules is essential to support life. In mammals, iron exists mostly in the form of heme, enclosed within an organic protoporphyrin ring and functioning primarily as a prosthetic group in proteins. Paradoxically, free iron also has the potential to become cytotoxic when electron exchange with oxygen is unrestricted and catalyzes the production of reactive oxygen species. These biological properties demand that iron metabolism is tightly regulated such that iron is available for core biological functions whilst preventing its cytotoxic effects. Macrophages play a central role in establishing this delicate balance. Here, we review the impact of macrophages on heme-iron metabolism and, reciprocally, how heme-iron modulates macrophage function. äMacrophages and iron metabolism (epmc).pdf DeepDyve Pubget Overpricing