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2016 ; 2016
(ä): 2015251
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Clinical Characteristics and 30-Day Outcomes of Intermittent Hemodialysis for
Acute Kidney Injury in an African Intensive Care Unit
#MMPMID27042657
Kwizera A
; Tumukunde J
; Ssemogerere L
; Ayebale E
; Agaba P
; Yakubu J
; Lubikire A
; Nabukenya M
; Kalyesubula R
Biomed Res Int
2016[]; 2016
(ä): 2015251
PMID27042657
show ga
INTRODUCTION: Acute kidney injury (AKI) is a common occurrence in the intensive
care unit (ICU). Studies have looked at outcomes of renal replacement therapy
using intermittent haemodialysis (IHD) in ICUs with varying results. Little is
known about the outcomes of using IHD in resource-limited settings where
continuous renal replacement therapy (CRRT) is limited. We sought to determine
outcomes of IHD among critically ill patients admitted to a low-income country
ICU. METHODS: A retrospective review of patient records was conducted. Patients
admitted to the ICU who underwent IHD for AKI were included in the study.
Patients' demographic and clinical characteristics, cause of AKI, laboratory
parameters, haemodialysis characteristics, and survival were interpreted and
analyzed. Primary outcome was mortality. RESULTS: Of 62 patients, 40 had complete
records. Median age of patients was 38.5 years. Etiologic diagnoses associated
with AKI included sepsis, malaria, and ARDS. Mortality was 52.5%. APACHE II (OR
4.550; 95% CI 1.2-17.5, p = 0.028), mechanical ventilation (OR 13.063; 95% CI
2.3-72, p = 0.003), and need for vasopressors (OR 16.8; 95% CI 3.4-82.6, p =
0.001) had statistically significant association with mortality. CONCLUSION: IHD
may be a feasible alternative for RRT in critically ill haemodynamically stable
patients in low resource settings where CRRT may not be available.