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10.1016/j.celrep.2016.02.035 http://scihub22266oqcxt.onion/10.1016/j.celrep.2016.02.035 C4794398!4794398!26947080     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Rep 2016 ; 14 (10): 2289-300 Nephropedia Template TP {{tp|p=26947080|t=2016. p73 is Required for Multiciliogenesis and Regulates the Foxj1-Associated Gene Network |pdf=|usr=}}{{26947080}} gab.com Text p73 is Required for Multiciliogenesis and Regulates the Foxj1-Associated Gene Network JO: Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=26947080 #FOAvip We report that p73 is expressed in multiciliated cells (MCCs), is required for MCC differentiation, and directly regulates transcriptional modulators of multiciliogenesis. Loss of ciliary biogenesis provides a unifying mechanism for many phenotypes observed in p73 knockout mice including hydrocephalus, hippocampal dysgenesis, sterility and chronic inflammation/infection of lung, middle ear and sinus. Through p73 and p63 ChIP-seq using murine tracheal cells, we identified over 100 putative p73 target genes that regulate MCC differentiation and homeostasis. We validated Foxj1, a transcriptional regulator of multiciliogenesis, and many other cilia-associated genes as direct target genes of p73 and p63. We show p73 and p63 are co-expressed in a subset of basal cells, and suggest that p73 ?marks? these cells for MCC differentiation. In sum, p73 is essential for MCC differentiation, functions as a critical regulator of a transcriptome required for MCC differentiation and, like p63, has an essential role in development of tissues. Twit Text FOAVip p73 is Required for Multiciliogenesis and Regulates the Foxj1-Associated Gene Network ????Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=26947080 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26947080 #FOAvip English Wikipedia <ref>{{Cite pmid|26947080}}</ref> p73 is Required for Multiciliogenesis and Regulates the Foxj1-Associated Gene Network #MMPMID26947080 Marshall CB; Mays DJ; Beeler JS; Rosenbluth JM; Boyd KL; Guasch GLS; Shaver TM; Tang LJ; Liu Q; Shyr Y; Venters BJ; Magnuson MA; Pietenpol JA Cell Rep 2016[Mar]; 14 (10): 2289-300 PMID26947080show ga We report that p73 is expressed in multiciliated cells (MCCs), is required for MCC differentiation, and directly regulates transcriptional modulators of multiciliogenesis. Loss of ciliary biogenesis provides a unifying mechanism for many phenotypes observed in p73 knockout mice including hydrocephalus, hippocampal dysgenesis, sterility and chronic inflammation/infection of lung, middle ear and sinus. Through p73 and p63 ChIP-seq using murine tracheal cells, we identified over 100 putative p73 target genes that regulate MCC differentiation and homeostasis. We validated Foxj1, a transcriptional regulator of multiciliogenesis, and many other cilia-associated genes as direct target genes of p73 and p63. We show p73 and p63 are co-expressed in a subset of basal cells, and suggest that p73 ?marks? these cells for MCC differentiation. In sum, p73 is essential for MCC differentiation, functions as a critical regulator of a transcriptome required for MCC differentiation and, like p63, has an essential role in development of tissues. äp73 is Required for Multiciliogenesis and Regulates the Foxj1-Associat(epmc).pdf DeepDyve Pubget Overpricing