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10.1016/j.immuni.2016.02.010 http://scihub22266oqcxt.onion/10.1016/j.immuni.2016.02.010 C4794380!4794380!26948373     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Immunity 2016 ; 44 (3): 542-52 Nephropedia Template TP {{tp|p=26948373|t=2016. Complex Antigens Elicit Diverse Patterns of Clonal Selection in Germinal Centers |pdf=|usr=}}{{26948373}} gab.com Text Complex Antigens Elicit Diverse Patterns of Clonal Selection in Germinal Centers JO: Immunity http://www.kidney.de/pget.php?&tw=1&pmid=26948373 #FOAvip Germinal center (GC) B cells evolve towards increased affinity by a Darwinian process that has been studied primarily in genetically restricted, hapten-specific responses. We explored the population dynamics of genetically diverse GC responses to two complex antigens ? Bacillus anthracis protective antigen and influenza hemagglutinin ? in which B cells competed both intra- and interclonally for distinct epitopes. Preferred VH rearrangements among antigen-binding, naïve B cells were similarly abundant in early GCs but, unlike responses to haptens, clonal diversity increased in GC B cells as early ?winners? were replaced by rarer, high-affinity clones. Despite affinity maturation, inter- and intraclonal avidities varied greatly, and half of GC B cells did not bind the immunogen but nonetheless exhibited biased VH use, V(D)J mutation, and clonal expansion comparable to antigen-binding cells. GC reactions to complex antigens permit a range of specificities and affinities, with potential advantages for broad protection. Twit Text FOAVip Complex Antigens Elicit Diverse Patterns of Clonal Selection in Germinal Centers ????Immunity http://www.kidney.de/pget.php?&tw=1&pmid=26948373 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26948373 #FOAvip English Wikipedia <ref>{{Cite pmid|26948373}}</ref> Complex Antigens Elicit Diverse Patterns of Clonal Selection in Germinal Centers #MMPMID26948373 Kuraoka M; Schmidt AG; Nojima T; Feng F; Watanabe A; Kitamura D; Harrison SC; Kepler TB; Kelsoe G Immunity 2016[Mar]; 44 (3): 542-52 PMID26948373show ga Germinal center (GC) B cells evolve towards increased affinity by a Darwinian process that has been studied primarily in genetically restricted, hapten-specific responses. We explored the population dynamics of genetically diverse GC responses to two complex antigens ? Bacillus anthracis protective antigen and influenza hemagglutinin ? in which B cells competed both intra- and interclonally for distinct epitopes. Preferred VH rearrangements among antigen-binding, naïve B cells were similarly abundant in early GCs but, unlike responses to haptens, clonal diversity increased in GC B cells as early ?winners? were replaced by rarer, high-affinity clones. Despite affinity maturation, inter- and intraclonal avidities varied greatly, and half of GC B cells did not bind the immunogen but nonetheless exhibited biased VH use, V(D)J mutation, and clonal expansion comparable to antigen-binding cells. GC reactions to complex antigens permit a range of specificities and affinities, with potential advantages for broad protection. äComplex Antigens Elicit Diverse Patterns of Clonal Selection in Germin(epmc).pdf DeepDyve Pubget Overpricing