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10.3109/10428194.2015.1106533 http://scihub22266oqcxt.onion/10.3109/10428194.2015.1106533 C4794359!4794359!26643954     free     free     free       Leuk+Lymphoma 2016 ; 57 (4): 758-65 Nephropedia Template TP {{tp|p=26643954|t=2016. Metabolism pathways in chronic lymphocytic leukemia |pdf=|usr=}}{{26643954}} gab.com Text Metabolism pathways in chronic lymphocytic leukemia JO: Leuk Lymphoma http://www.kidney.de/pget.php?&tw=1&pmid=26643954 #FOAvip Alterations in CLL cell metabolism have been studied by several investigators. Unlike normal B lymphocytes or other leukemia cells, CLL cells, like adipocytes, store lipids and utilize free fatty acids (FFA) to produce chemical energy. None of the recently identified mutations in CLL directly affects metabolic pathways, suggesting that genetic alterations do not directly contribute to CLL cells? metabolic reprogramming. Conversely, recent data suggest that activation of STAT3 or downregulation of microRNA-125 levels plays a crucial role in the utilization of FFA to meet CLL cells? metabolic needs. STAT3, known to be constitutively activated in CLL, increases the levels of lipoprotein lipase that mediates lipoprotein uptake and shifts CLL cells? metabolism towards utilization of FFA. Herein we review the evidence for altered lipid metabolism, increased mitochondrial activity, and formation of reactive oxygen species in CLL cells, and discuss possible therapeutic strategies to inhibit lipid metabolism pathways in patient with CLL. Twit Text FOAVip Metabolism pathways in chronic lymphocytic leukemia ????Leuk Lymphoma http://www.kidney.de/pget.php?&tw=1&pmid=26643954 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26643954 #FOAvip English Wikipedia <ref>{{Cite pmid|26643954}}</ref> Metabolism pathways in chronic lymphocytic leukemia #MMPMID26643954 Rozovski U; Hazan-Halevy I; Barzilay M; Keating MJ; Estrov Z Leuk Lymphoma 2016[Apr]; 57 (4): 758-65 PMID26643954show ga Alterations in CLL cell metabolism have been studied by several investigators. Unlike normal B lymphocytes or other leukemia cells, CLL cells, like adipocytes, store lipids and utilize free fatty acids (FFA) to produce chemical energy. None of the recently identified mutations in CLL directly affects metabolic pathways, suggesting that genetic alterations do not directly contribute to CLL cells? metabolic reprogramming. Conversely, recent data suggest that activation of STAT3 or downregulation of microRNA-125 levels plays a crucial role in the utilization of FFA to meet CLL cells? metabolic needs. STAT3, known to be constitutively activated in CLL, increases the levels of lipoprotein lipase that mediates lipoprotein uptake and shifts CLL cells? metabolism towards utilization of FFA. Herein we review the evidence for altered lipid metabolism, increased mitochondrial activity, and formation of reactive oxygen species in CLL cells, and discuss possible therapeutic strategies to inhibit lipid metabolism pathways in patient with CLL. äMetabolism pathways in chronic lymphocytic leukemia (epmc).pdf DeepDyve Pubget Overpricing