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10.1016/j.immuni.2016.01.001 http://scihub22266oqcxt.onion/10.1016/j.immuni.2016.01.001 C4794358!4794358!26921108     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Immunity 2016 ; 44 (3): 582-96 Nephropedia Template TP {{tp|p=26921108|t=2016. Macrophage Akt1 kinase-mediated mitophagy modulates apoptosis resistance and pulmonary fibrosis |pdf=|usr=}}{{26921108}} gab.com Text Macrophage Akt1 kinase-mediated mitophagy modulates apoptosis resistance and pulmonary fibrosis JO: Immunity http://www.kidney.de/pget.php?&tw=1&pmid=26921108 #FOAvip Idiopathic pulmonary fibrosis (IPF) is a devastating lung disorder with increasing incidence. Mitochondrial oxidative stress in alveolar macrophages is directly linked to pulmonary fibrosis. Mitophagy, the selective engulfment of dysfunctional mitochondria by autophagasomes, is important for cellular homeostasis and can be induced by mitochondrial oxidative stress. Here, we show Akt1 induced macrophage mitochondrial reactive oxygen species (ROS) and mitophagy. Mice harboring a conditional deletion of Akt1 in macrophages (Akt1?/?Lyz2-cre) and Park2?/? mice had impaired mitophagy and reduced active transforming growth factor-?1 (TGF-?1). Although Akt1 increased TGF-?1 expression, mitophagy inhibition in Akt1-overexpressing macrophages abrogated TGF-?1 expression and fibroblast differentiation. Importantly, conditional Akt1?/? Lyz2-cre mice and Park2?/? mice had increased macrophage apoptosis and were protected from pulmonary fibrosis. Moreover, IPF alveolar macrophages had evidence of increased mitophagy and display apoptosis resistance. These observations suggest that Akt1-mediated mitophagy contributes to alveolar macrophage apoptosis resistance and is required for pulmonary fibrosis development. Twit Text FOAVip Macrophage Akt1 kinase-mediated mitophagy modulates apoptosis resistance and pulmonary fibrosis ????Immunity http://www.kidney.de/pget.php?&tw=1&pmid=26921108 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26921108 #FOAvip English Wikipedia <ref>{{Cite pmid|26921108}}</ref> Macrophage Akt1 kinase-mediated mitophagy modulates apoptosis resistance and pulmonary fibrosis #MMPMID26921108 Larson-Casey JL; Deshane JS; Ryan AJ; Thannickal VJ; Carter AB Immunity 2016[Mar]; 44 (3): 582-96 PMID26921108show ga Idiopathic pulmonary fibrosis (IPF) is a devastating lung disorder with increasing incidence. Mitochondrial oxidative stress in alveolar macrophages is directly linked to pulmonary fibrosis. Mitophagy, the selective engulfment of dysfunctional mitochondria by autophagasomes, is important for cellular homeostasis and can be induced by mitochondrial oxidative stress. Here, we show Akt1 induced macrophage mitochondrial reactive oxygen species (ROS) and mitophagy. Mice harboring a conditional deletion of Akt1 in macrophages (Akt1?/?Lyz2-cre) and Park2?/? mice had impaired mitophagy and reduced active transforming growth factor-?1 (TGF-?1). Although Akt1 increased TGF-?1 expression, mitophagy inhibition in Akt1-overexpressing macrophages abrogated TGF-?1 expression and fibroblast differentiation. Importantly, conditional Akt1?/? Lyz2-cre mice and Park2?/? mice had increased macrophage apoptosis and were protected from pulmonary fibrosis. Moreover, IPF alveolar macrophages had evidence of increased mitophagy and display apoptosis resistance. These observations suggest that Akt1-mediated mitophagy contributes to alveolar macrophage apoptosis resistance and is required for pulmonary fibrosis development. äMacrophage Akt1 kinase-mediated mitophagy modulates apoptosis resistan(epmc).pdf DeepDyve Pubget Overpricing