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10.1016/j.it.2008.05.002 http://scihub22266oqcxt.onion/10.1016/j.it.2008.05.002 C4794280!4794280!18599350     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=18599350&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Trends+Immunol 2008 ; 29 (8): 357-65 Nephropedia Template TP {{tp|p=18599350|t=2008. Why neurodegenerative diseases are progressive: uncontrolled inflammation drives disease progression |pdf=|usr=}}{{18599350}} gab.com Text Why neurodegenerative diseases are progressive: uncontrolled inflammation drives disease progression JO: Trends Immunol http://www.kidney.de/pget.php?&tw=1&pmid=18599350 #FOAvip Neurodegenerative diseases are a group of chronic, progressive disorders characterized by the gradual loss of neurons in discrete areas of the central nervous system (CNS). The mechanism(s) underlying their progressive nature remains unknown but a timely and well-controlled inflammatory reaction is essential for the integrity and proper function of the CNS. Substantial evidence has documented a common inflammatory mechanism in various neurodegenerative diseases. We hypothesize that in the diseased CNS, interactions between damaged neurons and dysregulated, overactivated microglia create a vicious self-propagating cycle causing uncontrolled, prolonged inflammation that drives the chronic progression of neurodegenerative diseases. We further propose that dynamic modulation of this inflammatory reaction by interrupting the vicious cycle might become a disease-modifying therapeutic strategy for neurodegenerative diseases. Twit Text FOAVip Why neurodegenerative diseases are progressive: uncontrolled inflammation drives disease progression ????Trends Immunol http://www.kidney.de/pget.php?&tw=1&pmid=18599350 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=18599350 #FOAvip English Wikipedia <ref>{{Cite pmid|18599350}}</ref> Why neurodegenerative diseases are progressive: uncontrolled inflammation drives disease progression #MMPMID18599350 Gao HM; Hong JS Trends Immunol 2008[Aug]; 29 (8): 357-65 PMID18599350show ga Neurodegenerative diseases are a group of chronic, progressive disorders characterized by the gradual loss of neurons in discrete areas of the central nervous system (CNS). The mechanism(s) underlying their progressive nature remains unknown but a timely and well-controlled inflammatory reaction is essential for the integrity and proper function of the CNS. Substantial evidence has documented a common inflammatory mechanism in various neurodegenerative diseases. We hypothesize that in the diseased CNS, interactions between damaged neurons and dysregulated, overactivated microglia create a vicious self-propagating cycle causing uncontrolled, prolonged inflammation that drives the chronic progression of neurodegenerative diseases. We further propose that dynamic modulation of this inflammatory reaction by interrupting the vicious cycle might become a disease-modifying therapeutic strategy for neurodegenerative diseases. äWhy neurodegenerative diseases are progressive: uncontrolled inflammat(epmc).pdf DeepDyve Pubget Overpricing