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10.1177/0271678X15614589 http://scihub22266oqcxt.onion/10.1177/0271678X15614589 C4794098!4794098!26661222     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Cereb+Blood+Flow+Metab 2016 ; 36 (3): 476-86 Nephropedia Template TP {{tp|p=26661222|t=2016. Pharmacologic manipulation of lysosomal enzyme transport across the blood?brain barrier |pdf=|usr=}}{{26661222}} gab.com Text Pharmacologic manipulation of lysosomal enzyme transport across the blood brain barrier JO: J Cereb Blood Flow Metab http://www.kidney.de/pget.php?&tw=1&pmid=26661222 #FOAvip The adult blood?brain barrier, unlike the neonatal blood?brain barrier, does not transport lysosomal enzymes into brain, making enzyme replacement therapy ineffective in treating the central nervous system symptoms of lysosomal storage diseases. However, enzyme transport can be re-induced with alpha-adrenergics. Here, we examined agents that are known to alter the blood?brain barrier transport of large molecules or to induce lysosomal enzyme transport across the blood?brain barrier ((±)epinephrine, insulin, retinoic acid, and lipopolysaccharide) in 2-week-old and adult mice. In 2-week-old adolescent mice, all these pharmacologic agents increased brain and heart uptake of phosphorylated human ?-glucuronidase. In 8-week-old adult mice, manipulations with (±)epinephrine, insulin, and retinoic acid were significantly effective on uptake by brain and heart. The increased uptake of phosphorylated human  ?-glucuronidase was inhibited by mannose 6-phosphate for the agents (±)epinephrine and retinoic acid and by L-NG-nitroarginine methyl ester for the agent lipopolysaccharide in neonatal and adult mice. An in situ brain perfusion study revealed that retinoic acid directly modulated the transport of phosphorylated human ?-glucuronidase across the blood?brain barrier. The present study indicates that there are multiple opportunities to at least transiently induce phosphorylated human ?-glucuronidase transport at the adult blood?brain barrier. Twit Text FOAVip Pharmacologic manipulation of lysosomal enzyme transport across the blood brain barrier ????J Cereb Blood Flow Metab http://www.kidney.de/pget.php?&tw=1&pmid=26661222 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26661222 #FOAvip English Wikipedia <ref>{{Cite pmid|26661222}}</ref> Pharmacologic manipulation of lysosomal enzyme transport across the blood?brain barrier #MMPMID26661222 Urayama A; Grubb JH; Sly WS; Banks WA J Cereb Blood Flow Metab 2016[Mar]; 36 (3): 476-86 PMID26661222show ga The adult blood?brain barrier, unlike the neonatal blood?brain barrier, does not transport lysosomal enzymes into brain, making enzyme replacement therapy ineffective in treating the central nervous system symptoms of lysosomal storage diseases. However, enzyme transport can be re-induced with alpha-adrenergics. Here, we examined agents that are known to alter the blood?brain barrier transport of large molecules or to induce lysosomal enzyme transport across the blood?brain barrier ((±)epinephrine, insulin, retinoic acid, and lipopolysaccharide) in 2-week-old and adult mice. In 2-week-old adolescent mice, all these pharmacologic agents increased brain and heart uptake of phosphorylated human ?-glucuronidase. In 8-week-old adult mice, manipulations with (±)epinephrine, insulin, and retinoic acid were significantly effective on uptake by brain and heart. The increased uptake of phosphorylated human  ?-glucuronidase was inhibited by mannose 6-phosphate for the agents (±)epinephrine and retinoic acid and by L-NG-nitroarginine methyl ester for the agent lipopolysaccharide in neonatal and adult mice. An in situ brain perfusion study revealed that retinoic acid directly modulated the transport of phosphorylated human ?-glucuronidase across the blood?brain barrier. The present study indicates that there are multiple opportunities to at least transiently induce phosphorylated human ?-glucuronidase transport at the adult blood?brain barrier. äPharmacologic manipulation of lysosomal enzyme transport across the bl(epmc).pdf DeepDyve Pubget Overpricing