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10.1016/j.trsl.2014.05.003

http://scihub22266oqcxt.onion/10.1016/j.trsl.2014.05.003
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C4793962!4793962!24880148
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suck abstract from ncbi


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pmid24880148      Transl+Res 2015 ; 165 (1): 36-47
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  • The Nucleosome Remodeling and Deacetylase (NuRD) Complex in Development and Disease #MMPMID24880148
  • Basta J; Rauchman M
  • Transl Res 2015[Jan]; 165 (1): 36-47 PMID24880148show ga
  • The Nucleosome Remodeling and Deacetylase (NuRD) complex is one of the major chromatin remodeling complexes found in cells. It plays an important role in regulating gene transcription, genome integrity and cell cycle progression. Through its impact on these basic cellular processes, increasing evidence indicates that alterations in the activity of this macromolecular complex can lead to developmental defects, oncogenesis and accelerated ageing. Recent genetic and biochemical studies have elucidated the mechanisms of NuRD action in modifying the chromatin landscape. These advances have the potential to lead to new therapeutic approaches to birth defects and cancer.
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