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10.1016/j.bios.2016.02.026

http://scihub22266oqcxt.onion/10.1016/j.bios.2016.02.026
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C4793915!4793915 !26901461
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suck abstract from ncbi


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pmid26901461
      Biosens+Bioelectron 2016 ; 80 (ä): 647-653
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  • Using DNA devices to track anticancer drug activity #MMPMID26901461
  • Kahanda D ; Chakrabarti G ; Mcwilliams MA ; Boothman DA ; Slinker JD
  • Biosens Bioelectron 2016[Jun]; 80 (ä): 647-653 PMID26901461 show ga
  • It is beneficial to develop systems that reproduce complex reactions of biological systems while maintaining control over specific factors involved in such processes. We demonstrated a DNA device for following the repair of DNA damage produced by a redox-cycling anticancer drug, beta-lapachone (?-lap). These chips supported ß-lap-induced biological redox cycle and tracked subsequent DNA damage repair activity with redox-modified DNA monolayers on gold. We observed drug-specific changes in square wave voltammetry from these chips at therapeutic ß-lap concentrations of high statistical significance over drug-free control. We also demonstrated a high correlation of this change with the specific ß-lap-induced redox cycle using rational controls. The concentration dependence of ß-lap revealed significant signal changes at levels of high clinical significance as well as sensitivity to sub-lethal levels of ß-lap. Catalase, an enzyme decomposing peroxide, was found to suppress DNA damage at a NQO1/catalase ratio found in healthy cells, but was clearly overcome at a higher NQO1/catalase ratio consistent with cancer cells. We found that it was necessary to reproduce key features of the cellular environment to observe this activity. Thus, this chip-based platform enabled tracking of ß-lap-induced DNA damage repair when biological criteria were met, providing a unique synthetic platform for uncovering activity normally confined to inside cells.
  • |*Biosensing Techniques [MESH]
  • |*DNA Repair [MESH]
  • |Antineoplastic Agents/*pharmacology [MESH]
  • |Catalase/chemistry [MESH]
  • |Cell Line, Tumor [MESH]
  • |DNA Damage/drug effects [MESH]
  • |Gold/chemistry [MESH]
  • |Humans [MESH]
  • |NAD(P)H Dehydrogenase (Quinone)/chemistry [MESH]


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