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10.1016/j.bios.2016.02.026 http://scihub22266oqcxt.onion/10.1016/j.bios.2016.02.026 C4793915!4793915 !26901461     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26901461 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26901461 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Biosens+Bioelectron 2016 ; 80 (ä): 647-653 Nephropedia Template TP {{tp|p=26901461 |t=2016. Using DNA devices to track anticancer drug activity |pdf=|usr=}}{{26901461 }} gab.com Text Using DNA devices to track anticancer drug activity JO: Biosens Bioelectron http://www.kidney.de/pget.php?&tw=1&pmid=26901461 #FOAvip It is beneficial to develop systems that reproduce complex reactions of biological systems while maintaining control over specific factors involved in such processes. We demonstrated a DNA device for following the repair of DNA damage produced by a redox-cycling anticancer drug, beta-lapachone (?-lap). These chips supported ß-lap-induced biological redox cycle and tracked subsequent DNA damage repair activity with redox-modified DNA monolayers on gold. We observed drug-specific changes in square wave voltammetry from these chips at therapeutic ß-lap concentrations of high statistical significance over drug-free control. We also demonstrated a high correlation of this change with the specific ß-lap-induced redox cycle using rational controls. The concentration dependence of ß-lap revealed significant signal changes at levels of high clinical significance as well as sensitivity to sub-lethal levels of ß-lap. Catalase, an enzyme decomposing peroxide, was found to suppress DNA damage at a NQO1/catalase ratio found in healthy cells, but was clearly overcome at a higher NQO1/catalase ratio consistent with cancer cells. We found that it was necessary to reproduce key features of the cellular environment to observe this activity. Thus, this chip-based platform enabled tracking of ß-lap-induced DNA damage repair when biological criteria were met, providing a unique synthetic platform for uncovering activity normally confined to inside cells. Twit Text FOAVip Using DNA devices to track anticancer drug activity ????Biosens Bioelectron http://www.kidney.de/pget.php?&tw=1&pmid=26901461 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26901461 #FOAvip English Wikipedia <ref>{{Cite pmid|26901461 }}</ref> Using DNA devices to track anticancer drug activity #MMPMID26901461 Kahanda D ; Chakrabarti G ; Mcwilliams MA ; Boothman DA ; Slinker JD Biosens Bioelectron 2016[Jun]; 80 (ä): 647-653 PMID26901461 show ga It is beneficial to develop systems that reproduce complex reactions of biological systems while maintaining control over specific factors involved in such processes. We demonstrated a DNA device for following the repair of DNA damage produced by a redox-cycling anticancer drug, beta-lapachone (?-lap). These chips supported ß-lap-induced biological redox cycle and tracked subsequent DNA damage repair activity with redox-modified DNA monolayers on gold. We observed drug-specific changes in square wave voltammetry from these chips at therapeutic ß-lap concentrations of high statistical significance over drug-free control. We also demonstrated a high correlation of this change with the specific ß-lap-induced redox cycle using rational controls. The concentration dependence of ß-lap revealed significant signal changes at levels of high clinical significance as well as sensitivity to sub-lethal levels of ß-lap. Catalase, an enzyme decomposing peroxide, was found to suppress DNA damage at a NQO1/catalase ratio found in healthy cells, but was clearly overcome at a higher NQO1/catalase ratio consistent with cancer cells. We found that it was necessary to reproduce key features of the cellular environment to observe this activity. Thus, this chip-based platform enabled tracking of ß-lap-induced DNA damage repair when biological criteria were met, providing a unique synthetic platform for uncovering activity normally confined to inside cells. |*Biosensing Techniques [MESH] |*DNA Repair [MESH] |Antineoplastic Agents/*pharmacology [MESH] |Catalase/chemistry [MESH] |Cell Line, Tumor [MESH] |DNA Damage/drug effects [MESH] |Gold/chemistry [MESH] |Humans [MESH] |NAD(P)H Dehydrogenase (Quinone)/chemistry [MESH]Using DNA devices to track anticancer drug activity (epmc).pdf DeepDyve Pubget Overpricing