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10.1038/nrclinonc.2009.14 http://scihub22266oqcxt.onion/10.1038/nrclinonc.2009.14 C4793889!4793889!19333229     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Rev+Clin+Oncol 2009 ; 6 (4): 229-36 Nephropedia Template TP {{tp|p=19333229|t=2009. VEGF inhibitors in the treatment of cerebral edema in patients with brain cancer |pdf=|usr=}}{{19333229}} gab.com Text VEGF inhibitors in the treatment of cerebral edema in patients with brain cancer JO: Nat Rev Clin Oncol http://www.kidney.de/pget.php?&tw=1&pmid=19333229 #FOAvip Most brain tumors oversecrete vascular endothelial growth factor (VEGF), which leads to an abnormally permeable tumor vasculature. This hyperpermeability allows fluid to leak from the intravascular space into the brain parenchyma, which causes vasogenic cerebral edema and increased interstitial fluid pressure. Increased interstitial fluid pressure has an important role in treatment resistance by contributing to tumor hypoxia and preventing adequate tumor penetration of chemotherapy agents. In addition, edema and the corticosteroids needed to control cerebral edema cause significant morbidity and mortality. Agents that block the VEGF pathway are able to decrease vascular permeability and, thus, cerebral edema, by restoring the abnormal tumor vasculature to a more normal state. Decreasing cerebral edema minimizes the adverse effects of corticosteroids and could improve clinical outcomes. Anti-VEGF agents might also be useful in other cancer-related conditions that increase vascular permeability, such as malignant pleural effusions or ascites. Twit Text FOAVip VEGF inhibitors in the treatment of cerebral edema in patients with brain cancer ????Nat Rev Clin Oncol http://www.kidney.de/pget.php?&tw=1&pmid=19333229 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=19333229 #FOAvip English Wikipedia <ref>{{Cite pmid|19333229}}</ref> VEGF inhibitors in the treatment of cerebral edema in patients with brain cancer #MMPMID19333229 Gerstner ER; Duda DG; di Tomaso E; Ryg PA; Loeffler JS; Sorensen AG; Ivy P; Jain RK; Batchelor TT Nat Rev Clin Oncol 2009[Apr]; 6 (4): 229-36 PMID19333229show ga Most brain tumors oversecrete vascular endothelial growth factor (VEGF), which leads to an abnormally permeable tumor vasculature. This hyperpermeability allows fluid to leak from the intravascular space into the brain parenchyma, which causes vasogenic cerebral edema and increased interstitial fluid pressure. Increased interstitial fluid pressure has an important role in treatment resistance by contributing to tumor hypoxia and preventing adequate tumor penetration of chemotherapy agents. In addition, edema and the corticosteroids needed to control cerebral edema cause significant morbidity and mortality. Agents that block the VEGF pathway are able to decrease vascular permeability and, thus, cerebral edema, by restoring the abnormal tumor vasculature to a more normal state. Decreasing cerebral edema minimizes the adverse effects of corticosteroids and could improve clinical outcomes. Anti-VEGF agents might also be useful in other cancer-related conditions that increase vascular permeability, such as malignant pleural effusions or ascites. äVEGF inhibitors in the treatment of cerebral edema in patients with br(epmc).pdf DeepDyve Pubget Overpricing