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Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Parasit+Vectors 2016 ; 9 (ä): ä Nephropedia Template TP
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Horizontal transfer of ?-carbonic anhydrase genes from prokaryotes to protozoans, insects, and nematodes #MMPMID26983858
Parasit Vectors 2016[]; 9 (ä): ä PMID26983858show ga
Background: Horizontal gene transfer (HGT) is a movement of genetic information occurring outside of normal mating activities. It is especially common between prokaryotic endosymbionts and their protozoan, insect, and nematode hosts. Although beta carbonic anhydrase (?-CA) plays a crucial role in metabolic functions of many living organisms, the origin of ?-CA genes in eukaryotic species remains unclear. Methods: This study was conducted using phylogenetics, prediction of subcellular localization, and identification of ?-CA, transposase, integrase, and resolvase genes on the MGEs of bacteria. We also structurally analyzed ?-CAs from protozoans, insects, and nematodes and their putative prokaryotic common ancestors, by homology modelling. Results: Our investigations of a number of target genomes revealed that genes coding for transposase, integrase, resolvase, and conjugation complex proteins have been integrated with ?-CA gene sequences on mobile genetic elements (MGEs) which have facilitated the mobility of ?-CA genes from bacteria to protozoan, insect, and nematode species. The prokaryotic origin of protozoan, insect, and nematode ?-CA enzymes is supported by phylogenetic analyses, prediction of subcellular localization, and homology modelling. Conclusion: MGEs form a complete set of enzymatic tools, which are relevant to HGT of ?-CA gene sequences from prokaryotes to protozoans, insects, and nematodes. Electronic supplementary material: The online version of this article (doi:10.1186/s13071-016-1415-7) contains supplementary material, which is available to authorized users.