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Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Chem+Commun+(Camb) 2008 ; ä (25): 2837-47 Nephropedia Template TP
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The bioinorganic chemistry and associated immunology of chronic beryllium disease? #MMPMID18566702
Scott BL; McCleskey TM; Chaudhary A; Hong-Geller E; Gnanakaran S
Chem Commun (Camb) 2008[Jul]; ä (25): 2837-47 PMID18566702show ga
Chronic beryllium disease (CBD) is a debilitating, incurable, and often fatal disease that is caused by the inhalation of beryllium particulates. The growing use of beryllium in the modern world, in products ranging from computers to dental prosthetics (390 tons of beryllium in the US in the year 2000) necessitates a molecular based understanding of the disease in order to prevent and cure CBD. We have investigated the molecular basis of CBD at Los Alamos National Laboratory during the past six years, employing a multidisciplinary approach of bioinorganic chemistry and immunology. The results of this work, including speciation, inhalation and dissolution, and immunology will be discussed.