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10.1038/srep23204 http://scihub22266oqcxt.onion/10.1038/srep23204 C4793236!4793236 !26979938     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26979938 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Sci+Rep 2016 ; 6 (ä): 23204 Nephropedia Template TP {{tp|p=26979938 |t=2016. C9orf72 ablation causes immune dysregulation characterized by leukocyte expansion, autoantibody production, and glomerulonephropathy in mice |pdf=|usr=}}{{26979938 }} gab.com Text C9orf72 ablation causes immune dysregulation characterized by leukocyte expansion, autoantibody production, and glomerulonephropathy in mice JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26979938 #FOAvip The expansion of a hexanucleotide (GGGGCC) repeat in C9ORF72 is the most common cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Both the function of C9ORF72 and the mechanism by which the repeat expansion drives neuropathology are unknown. To examine whether C9ORF72 haploinsufficiency induces neurological disease, we created a C9orf72-deficient mouse line. Null mice developed a robust immune phenotype characterized by myeloid expansion, T cell activation, and increased plasma cells. Mice also presented with elevated autoantibodies and evidence of immune-mediated glomerulonephropathy. Collectively, our data suggest that C9orf72 regulates immune homeostasis and an autoimmune response reminiscent of systemic lupus erythematosus (SLE) occurs in its absence. We further imply that haploinsufficiency is unlikely to be the causative factor in C9ALS/FTD pathology. Twit Text FOAVip C9orf72 ablation causes immune dysregulation characterized by leukocyte expansion, autoantibody production, and glomerulonephropathy in mice ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26979938 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26979938 #FOAvip English Wikipedia <ref>{{Cite pmid|26979938 }}</ref> C9orf72 ablation causes immune dysregulation characterized by leukocyte expansion, autoantibody production, and glomerulonephropathy in mice #MMPMID26979938 Atanasio A ; Decman V ; White D ; Ramos M ; Ikiz B ; Lee HC ; Siao CJ ; Brydges S ; LaRosa E ; Bai Y ; Fury W ; Burfeind P ; Zamfirova R ; Warshaw G ; Orengo J ; Oyejide A ; Fralish M ; Auerbach W ; Poueymirou W ; Freudenberg J ; Gong G ; Zambrowicz B ; Valenzuela D ; Yancopoulos G ; Murphy A ; Thurston G ; Lai KM Sci Rep 2016[Mar]; 6 (ä): 23204 PMID26979938 show ga The expansion of a hexanucleotide (GGGGCC) repeat in C9ORF72 is the most common cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Both the function of C9ORF72 and the mechanism by which the repeat expansion drives neuropathology are unknown. To examine whether C9ORF72 haploinsufficiency induces neurological disease, we created a C9orf72-deficient mouse line. Null mice developed a robust immune phenotype characterized by myeloid expansion, T cell activation, and increased plasma cells. Mice also presented with elevated autoantibodies and evidence of immune-mediated glomerulonephropathy. Collectively, our data suggest that C9orf72 regulates immune homeostasis and an autoimmune response reminiscent of systemic lupus erythematosus (SLE) occurs in its absence. We further imply that haploinsufficiency is unlikely to be the causative factor in C9ALS/FTD pathology. |*Autoimmunity [MESH] |Animals [MESH] |Autoantibodies/*biosynthesis/blood [MESH] |C9orf72 Protein [MESH] |Cytokines/blood [MESH] |Female [MESH] |Glomerulonephritis, Membranoproliferative/blood/*genetics/immunology [MESH] |Guanine Nucleotide Exchange Factors/*genetics/metabolism [MESH] |Lupus Erythematosus, Systemic/genetics/immunology [MESH] |Lymphocyte Activation [MESH] |Lymphoid Tissue/pathology [MESH] |Macrophages/immunology [MESH] |Male [MESH] |Mice, 129 Strain [MESH] |Mice, Inbred C57BL [MESH] |Mice, Knockout [MESH] |Plasma Cells/immunology [MESH] |Sequence Analysis, RNA [MESH]C9orf72 ablation causes immune dysregulation characterized by leukocyt(epmc).pdf DeepDyve Pubget Overpricing