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2016 ; 6
(ä): 23096
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The Ultrastructures and Mechanical Properties of the Descement s Membrane in
Fuchs Endothelial Corneal Dystrophy
#MMPMID26980551
Xia D
; Zhang S
; Nielsen E
; Ivarsen AR
; Liang C
; Li Q
; Thomsen K
; Hjortdal JØ
; Dong M
Sci Rep
2016[Mar]; 6
(ä): 23096
PMID26980551
show ga
Fuchs endothelial corneal dystrophy (FECD), is the most common corneal
endothelial dystrophy, and contributes up to 50% of all corneal transplantations
performed in developed countries. FECD develops in Descemet's membrane (DM) and
possibly alters the mechanical properties and internal structures in this basal
lamina. In this work, the morphology and mechanical properties of FECD-DMs are
studied by transmission electron microscopy (TEM) and quantitative dynamic atomic
force microscopy (QD-AFM) at nano scale. Pathological wide-space collagens that
are typical of FECD display different mechanical properties in that they are
softer than the remaining tissue both for dehydrated- and fully hydrated samples.
Additionally, the hydration level has major influence on the mechanical
properties. These findings could help to further understand the structural
changes in FECD, and possibly be useful for further characterization of the
disease, the diagnosis and assessment or even pathologic analysis.