Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1038/ncomms10791 http://scihub22266oqcxt.onion/10.1038/ncomms10791 C4793079!4793079 !26972847     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26972847 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26972847 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nat+Commun 2016 ; 7 (ä): 10791 Nephropedia Template TP {{tp|p=26972847 |t=2016. IL-1 receptor antagonist ameliorates inflammasome-dependent inflammation in murine and human cystic fibrosis |pdf=|usr=}}{{26972847 }} gab.com Text IL-1 receptor antagonist ameliorates inflammasome-dependent inflammation in murine and human cystic fibrosis JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=26972847 #FOAvip Dysregulated inflammasome activation contributes to respiratory infections and pathologic airway inflammation. Through basic and translational approaches involving murine models and human genetic epidemiology, we show here the importance of the different inflammasomes in regulating inflammatory responses in mice and humans with cystic fibrosis (CF), a life-threatening disorder of the lungs and digestive system. While both contributing to pathogen clearance, NLRP3 more than NLRC4 contributes to deleterious inflammatory responses in CF and correlates with defective NLRC4-dependent IL-1Ra production. Disease susceptibility in mice and microbial colonization in humans occurs in conditions of genetic deficiency of NLRC4 or IL-1Ra and can be rescued by administration of the recombinant IL-1Ra, anakinra. These results indicate that pathogenic NLRP3 activity in CF could be negatively regulated by IL-1Ra and provide a proof-of-concept evidence that inflammasomes are potential targets to limit the pathological consequences of microbial colonization in CF. Twit Text FOAVip IL-1 receptor antagonist ameliorates inflammasome-dependent inflammation in murine and human cystic fibrosis ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=26972847 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26972847 #FOAvip English Wikipedia <ref>{{Cite pmid|26972847 }}</ref> IL-1 receptor antagonist ameliorates inflammasome-dependent inflammation in murine and human cystic fibrosis #MMPMID26972847 Iannitti RG ; Napolioni V ; Oikonomou V ; De Luca A ; Galosi C ; Pariano M ; Massi-Benedetti C ; Borghi M ; Puccetti M ; Lucidi V ; Colombo C ; Fiscarelli E ; Lass-Flörl C ; Majo F ; Cariani L ; Russo M ; Porcaro L ; Ricciotti G ; Ellemunter H ; Ratclif L ; De Benedictis FM ; Talesa VN ; Dinarello CA ; van de Veerdonk FL ; Romani L Nat Commun 2016[Mar]; 7 (ä): 10791 PMID26972847 show ga Dysregulated inflammasome activation contributes to respiratory infections and pathologic airway inflammation. Through basic and translational approaches involving murine models and human genetic epidemiology, we show here the importance of the different inflammasomes in regulating inflammatory responses in mice and humans with cystic fibrosis (CF), a life-threatening disorder of the lungs and digestive system. While both contributing to pathogen clearance, NLRP3 more than NLRC4 contributes to deleterious inflammatory responses in CF and correlates with defective NLRC4-dependent IL-1Ra production. Disease susceptibility in mice and microbial colonization in humans occurs in conditions of genetic deficiency of NLRC4 or IL-1Ra and can be rescued by administration of the recombinant IL-1Ra, anakinra. These results indicate that pathogenic NLRP3 activity in CF could be negatively regulated by IL-1Ra and provide a proof-of-concept evidence that inflammasomes are potential targets to limit the pathological consequences of microbial colonization in CF. |Adolescent [MESH] |Adult [MESH] |Animals [MESH] |Apoptosis Regulatory Proteins/genetics/immunology [MESH] |Aspergillosis/*immunology [MESH] |Aspergillus fumigatus [MESH] |Autophagy/genetics/immunology [MESH] |Blotting, Western [MESH] |CARD Signaling Adaptor Proteins/genetics/immunology [MESH] |Calcium-Binding Proteins/genetics/immunology [MESH] |Carrier Proteins/genetics/immunology [MESH] |Cell Line [MESH] |Child [MESH] |Child, Preschool [MESH] |Cystic Fibrosis Transmembrane Conductance Regulator/genetics [MESH] |Cystic Fibrosis/genetics/*immunology/microbiology [MESH] |Cytokines/*genetics/immunology [MESH] |Disease Models, Animal [MESH] |Enzyme-Linked Immunosorbent Assay [MESH] |Epithelial Cells/*immunology [MESH] |Female [MESH] |Fluorescent Antibody Technique [MESH] |Humans [MESH] |Immunohistochemistry [MESH] |In Situ Nick-End Labeling [MESH] |Infant [MESH] |Inflammasomes/*genetics/immunology [MESH] |Inflammation [MESH] |Interleukin 1 Receptor Antagonist Protein/*genetics/immunology/pharmacology [MESH] |Lung/*metabolism [MESH] |Macrophages/immunology [MESH] |Male [MESH] |Mice [MESH] |Mice, Inbred C57BL [MESH] |Mice, Knockout [MESH] |Middle Aged [MESH] |NLR Family, Pyrin Domain-Containing 3 Protein [MESH] |Polymorphism, Single Nucleotide [MESH] |Pseudomonas Infections/*immunology [MESH] |Pseudomonas aeruginosa [MESH] |Respiratory Mucosa/cytology [MESH] |Reverse Transcriptase Polymerase Chain Reaction [MESH]IL-1 receptor antagonist ameliorates inflammasome-dependent inflammati(epmc).pdf DeepDyve Pubget Overpricing