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10.1038/ncomms10943 http://scihub22266oqcxt.onion/10.1038/ncomms10943 C4793078!4793078!26971449     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun 2016 ; 7 (ä): ä Nephropedia Template TP {{tp|p=26971449|t=2016. Promotion of mitochondrial biogenesis by necdin protects neurons against mitochondrial insults |pdf=|usr=}}{{26971449}} gab.com Text Promotion of mitochondrial biogenesis by necdin protects neurons against mitochondrial insults JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=26971449 #FOAvip Neurons rely heavily on mitochondria for their function and survival. Mitochondrial dysfunction contributes to the pathogenesis of neurodegenerative diseases such as Parkinson's disease. PGC-1? is a master regulator of mitochondrial biogenesis and function. Here we identify necdin as a potent PGC-1? stabilizer that promotes mitochondrial biogenesis via PGC-1? in mammalian neurons. Expression of genes encoding mitochondria-specific proteins decreases significantly in necdin-null cortical neurons, where mitochondrial function and expression of the PGC-1? protein are reduced. Necdin strongly stabilizes PGC-1? by inhibiting its ubiquitin-dependent degradation. Forced expression of necdin enhances mitochondrial function in primary cortical neurons and human SH-SY5Y neuroblastoma cells to prevent mitochondrial respiratory chain inhibitor-induced degeneration. Moreover, overexpression of necdin in the substantia nigra in vivo of adult mice protects dopaminergic neurons against degeneration in experimental Parkinson's disease. These data reveal that necdin promotes mitochondrial biogenesis through stabilization of endogenous PGC-1? to exert neuroprotection against mitochondrial insults. Twit Text FOAVip Promotion of mitochondrial biogenesis by necdin protects neurons against mitochondrial insults ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=26971449 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26971449 #FOAvip English Wikipedia <ref>{{Cite pmid|26971449}}</ref> Promotion of mitochondrial biogenesis by necdin protects neurons against mitochondrial insults #MMPMID26971449 Hasegawa K; Yasuda T; Shiraishi C; Fujiwara K; Przedborski S; Mochizuki H; Yoshikawa K Nat Commun 2016[]; 7 (ä): ä PMID26971449show ga Neurons rely heavily on mitochondria for their function and survival. Mitochondrial dysfunction contributes to the pathogenesis of neurodegenerative diseases such as Parkinson's disease. PGC-1? is a master regulator of mitochondrial biogenesis and function. Here we identify necdin as a potent PGC-1? stabilizer that promotes mitochondrial biogenesis via PGC-1? in mammalian neurons. Expression of genes encoding mitochondria-specific proteins decreases significantly in necdin-null cortical neurons, where mitochondrial function and expression of the PGC-1? protein are reduced. Necdin strongly stabilizes PGC-1? by inhibiting its ubiquitin-dependent degradation. Forced expression of necdin enhances mitochondrial function in primary cortical neurons and human SH-SY5Y neuroblastoma cells to prevent mitochondrial respiratory chain inhibitor-induced degeneration. Moreover, overexpression of necdin in the substantia nigra in vivo of adult mice protects dopaminergic neurons against degeneration in experimental Parkinson's disease. These data reveal that necdin promotes mitochondrial biogenesis through stabilization of endogenous PGC-1? to exert neuroprotection against mitochondrial insults. äPromotion of mitochondrial biogenesis by necdin protects neurons again(epmc).pdf DeepDyve Pubget Overpricing