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Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Genomics+Proteomics+Bioinformatics 2016 ; 14 (1): 42-54 Nephropedia Template TP
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Roles, Functions, and Mechanisms of Long Non-coding RNAs in Cancer #MMPMID26883671
Fang Y; Fullwood MJ
Genomics Proteomics Bioinformatics 2016[Feb]; 14 (1): 42-54 PMID26883671show ga
Long non-coding RNAs (lncRNAs) play important roles in cancer. They are involved in chromatin remodeling, as well as transcriptional and post-transcriptional regulation, through a variety of chromatin-based mechanisms and via cross-talk with other RNA species. lncRNAs can function as decoys, scaffolds, and enhancer RNAs. This review summarizes the characteristics of lncRNAs, including their roles, functions, and working mechanisms, describes methods for identifying and annotating lncRNAs, and discusses future opportunities for lncRNA-based therapies using antisense oligonucleotides.