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10.1016/j.gpb.2016.01.005

http://scihub22266oqcxt.onion/10.1016/j.gpb.2016.01.005
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C4792842!4792842!26876720
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suck abstract from ncbi

pmid26876720      Genomics+Proteomics+Bioinformatics 2016 ; 14 (1): 21-30
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  • Single-cell Transcriptome Study as Big Data #MMPMID26876720
  • Yu P; Lin W
  • Genomics Proteomics Bioinformatics 2016[Feb]; 14 (1): 21-30 PMID26876720show ga
  • The rapid growth of single-cell RNA-seq studies (scRNA-seq) demands efficient data storage, processing, and analysis. Big-data technology provides a framework that facilitates the comprehensive discovery of biological signals from inter-institutional scRNA-seq datasets. The strategies to solve the stochastic and heterogeneous single-cell transcriptome signal are discussed in this article. After extensively reviewing the available big-data applications of next-generation sequencing (NGS)-based studies, we propose a workflow that accounts for the unique characteristics of scRNA-seq data and primary objectives of single-cell studies.
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