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10.1093/ckj/sfv144 http://scihub22266oqcxt.onion/10.1093/ckj/sfv144 C4792619!4792619!26985368     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26985368&cmd=llinks): Failed to open stream: HTTP request failed! 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Acute kidney injury, long-term renal function and mortality in patients undergoing major abdominal surgery: a cohort analysis |pdf=|usr=}}{{26985368}} gab.com Text Acute kidney injury, long-term renal function and mortality in patients undergoing major abdominal surgery: a cohort analysis JO: Clin Kidney J http://www.kidney.de/pget.php?&tw=1&pmid=26985368 #FOAvip Background: Acute kidney injury (AKI) is frequent during hospitalization and may contribute to adverse consequences. We aimed to evaluate long-term adverse renal function and mortality after postoperative AKI in a cohort of patients undergoing major abdominal surgery. Methods: We performed a retrospective analysis of adult patients who underwent major non-vascular abdominal surgery between January 2010 and February 2011 at the Department of Surgery II of Hospital de Santa Maria?Centro Hospitalar Lisboa Norte, Portugal. Exclusion criteria were as follows: chronic kidney disease on renal replacement therapy, undergoing renal replacement therapy the week before surgery, death before discharge and loss to follow-up through January 2014. Patients were categorized according to the development of postoperative AKI in the first 48 h after surgery using the Kidney Disease: Improving Global Outcomes classification. AKI was defined by an increase in absolute serum creatinine (SCr) ?0.3 mg/dL or by a percentage increase in SCr ?50% and/or by a decrease in urine output to <0.5 mL/kg/h for >6 h. Adverse renal outcomes (need for long-term dialysis and/or a 25% decrease in estimated glomerular filtration rate after hospital discharge) and mortality after discharge were evaluated. Cumulative mortality was analysed with the Kaplan?Meier method and log-rank test and outcome predictive factors with the Cox regression. Significance was set at P < 0.05. Results: Of 390 selected patients, 72 (18.5%) developed postoperative AKI. The median follow-up was 38 months. Adverse renal outcomes and death after hospital discharge were more frequent among AKI patients (47.2 versus 22.0%, P < 0.0001; and 47.2 versus 20.5%, P < 0.0001, respectively). The 4 year cumulative probability of death was 44.4% for AKI patients, while it was 19.8% for patients with no AKI (log-rank test, P < 0.0001). In multivariate analysis, AKI was a risk factor for adverse renal outcomes (adjusted hazard ratio 1.6, P = 0.046) and mortality (adjusted hazard ratio 1.4, P = 0.043). Conclusions: AKI after major abdominal surgery was independently associated with the risk of long-term need for dialysis and/or renal function decline and with the risk of death after hospital discharge. Twit Text FOAVip Acute kidney injury, long-term renal function and mortality in patients undergoing major abdominal surgery: a cohort analysis ????Clin Kidney J http://www.kidney.de/pget.php?&tw=1&pmid=26985368 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26985368 #FOAvip English Wikipedia <ref>{{Cite pmid|26985368}}</ref> Acute kidney injury, long-term renal function and mortality in patients undergoing major abdominal surgery: a cohort analysis #MMPMID26985368 Gameiro J; Neves JB; Rodrigues N; Bekerman C; Melo MJ; Pereira M; Teixeira C; Mendes I; Jorge S; Rosa R; Lopes JA Clin Kidney J 2016[Apr]; 9 (2): 192-200 PMID26985368show ga Background: Acute kidney injury (AKI) is frequent during hospitalization and may contribute to adverse consequences. We aimed to evaluate long-term adverse renal function and mortality after postoperative AKI in a cohort of patients undergoing major abdominal surgery. Methods: We performed a retrospective analysis of adult patients who underwent major non-vascular abdominal surgery between January 2010 and February 2011 at the Department of Surgery II of Hospital de Santa Maria?Centro Hospitalar Lisboa Norte, Portugal. Exclusion criteria were as follows: chronic kidney disease on renal replacement therapy, undergoing renal replacement therapy the week before surgery, death before discharge and loss to follow-up through January 2014. Patients were categorized according to the development of postoperative AKI in the first 48 h after surgery using the Kidney Disease: Improving Global Outcomes classification. AKI was defined by an increase in absolute serum creatinine (SCr) ?0.3 mg/dL or by a percentage increase in SCr ?50% and/or by a decrease in urine output to <0.5 mL/kg/h for >6 h. Adverse renal outcomes (need for long-term dialysis and/or a 25% decrease in estimated glomerular filtration rate after hospital discharge) and mortality after discharge were evaluated. Cumulative mortality was analysed with the Kaplan?Meier method and log-rank test and outcome predictive factors with the Cox regression. Significance was set at P < 0.05. Results: Of 390 selected patients, 72 (18.5%) developed postoperative AKI. The median follow-up was 38 months. Adverse renal outcomes and death after hospital discharge were more frequent among AKI patients (47.2 versus 22.0%, P < 0.0001; and 47.2 versus 20.5%, P < 0.0001, respectively). The 4 year cumulative probability of death was 44.4% for AKI patients, while it was 19.8% for patients with no AKI (log-rank test, P < 0.0001). In multivariate analysis, AKI was a risk factor for adverse renal outcomes (adjusted hazard ratio 1.6, P = 0.046) and mortality (adjusted hazard ratio 1.4, P = 0.043). Conclusions: AKI after major abdominal surgery was independently associated with the risk of long-term need for dialysis and/or renal function decline and with the risk of death after hospital discharge. äAcute kidney injury, long-term renal function and mortality in patient(epmc).pdf DeepDyve Pubget Overpricing