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Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Clin+Kidney+J 2016 ; 9 (2): 205-10 Nephropedia Template TP
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Phoxilium® reduces hypophosphataemia and magnesium supplementation during continuous renal replacement therapy #MMPMID26985370
Godaly G; Carlsson O; Broman M
Clin Kidney J 2016[Apr]; 9 (2): 205-10 PMID26985370show ga
Background: Although associated with severe clinical complications, phosphate remains a neglected ion. Additionally, phosphate balance during continuous renal replacement therapy (CRRT) is complex and multifunctional. The present retrospective study investigated the effects of phosphate-containing CRRT fluid on phosphate homeostasis. Methods: We retrospectively analysed 112 patients treated with CRRT at Skåne University Hospital, Sweden. The control group was treated with Hemosol® B0 (no phosphate; n = 36) as dialysis and replacement fluid, while the study group received Phoxilium® (phosphate; n = 76) as dialysis fluid and Hemosol® B0 as replacement fluid. Results: Hypophosphataemia (<0.7 mM) occurred in 15% of the treatment days in the control group compared with 7% in the study group (P = 0.027). Magnesium substitution was reduced by 40% in the study group (P < 0.001). No differences in acid?base parameters were detected between the groups. Conclusions: In this larger cohort, we could confirm that Phoxilium® reduced the episodes of hypophosphataemia during CRRT. A beneficial effect on magnesium balance could also be observed.