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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Clin+Kidney+J
2016 ; 9
(2
): 205-10
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Phoxilium(®) reduces hypophosphataemia and magnesium supplementation during
continuous renal replacement therapy
#MMPMID26985370
Godaly G
; Carlsson O
; Broman M
Clin Kidney J
2016[Apr]; 9
(2
): 205-10
PMID26985370
show ga
BACKGROUND: Although associated with severe clinical complications, phosphate
remains a neglected ion. Additionally, phosphate balance during continuous renal
replacement therapy (CRRT) is complex and multifunctional. The present
retrospective study investigated the effects of phosphate-containing CRRT fluid
on phosphate homeostasis. METHODS: We retrospectively analysed 112 patients
treated with CRRT at Skåne University Hospital, Sweden. The control group was
treated with Hemosol(®) B0 (no phosphate; n = 36) as dialysis and replacement
fluid, while the study group received Phoxilium(®) (phosphate; n = 76) as
dialysis fluid and Hemosol(®) B0 as replacement fluid. RESULTS: Hypophosphataemia
(<0.7 mM) occurred in 15% of the treatment days in the control group compared
with 7% in the study group (P = 0.027). Magnesium substitution was reduced by 40%
in the study group (P < 0.001). No differences in acid-base parameters were
detected between the groups. CONCLUSIONS: In this larger cohort, we could confirm
that Phoxilium(®) reduced the episodes of hypophosphataemia during CRRT. A
beneficial effect on magnesium balance could also be observed.