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10.1093/ckj/sfv133

http://scihub22266oqcxt.onion/10.1093/ckj/sfv133
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suck abstract from ncbi


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pmid26985370
      Clin+Kidney+J 2016 ; 9 (2 ): 205-10
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  • Phoxilium(®) reduces hypophosphataemia and magnesium supplementation during continuous renal replacement therapy #MMPMID26985370
  • Godaly G ; Carlsson O ; Broman M
  • Clin Kidney J 2016[Apr]; 9 (2 ): 205-10 PMID26985370 show ga
  • BACKGROUND: Although associated with severe clinical complications, phosphate remains a neglected ion. Additionally, phosphate balance during continuous renal replacement therapy (CRRT) is complex and multifunctional. The present retrospective study investigated the effects of phosphate-containing CRRT fluid on phosphate homeostasis. METHODS: We retrospectively analysed 112 patients treated with CRRT at Skåne University Hospital, Sweden. The control group was treated with Hemosol(®) B0 (no phosphate; n = 36) as dialysis and replacement fluid, while the study group received Phoxilium(®) (phosphate; n = 76) as dialysis fluid and Hemosol(®) B0 as replacement fluid. RESULTS: Hypophosphataemia (<0.7 mM) occurred in 15% of the treatment days in the control group compared with 7% in the study group (P = 0.027). Magnesium substitution was reduced by 40% in the study group (P < 0.001). No differences in acid-base parameters were detected between the groups. CONCLUSIONS: In this larger cohort, we could confirm that Phoxilium(®) reduced the episodes of hypophosphataemia during CRRT. A beneficial effect on magnesium balance could also be observed.
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