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10.18632/oncotarget.6285 http://scihub22266oqcxt.onion/10.18632/oncotarget.6285 C4792599!4792599 !26539644     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26539644 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Oncotarget 2015 ; 6 (42 ): 44892-904 Nephropedia Template TP {{tp|p=26539644 |t=2015. Sensitivity of human pleural mesothelioma to oncolytic measles virus depends on defects of the type I interferon response |pdf=|usr=}}{{26539644 }} gab.com Text Sensitivity of human pleural mesothelioma to oncolytic measles virus depends on defects of the type I interferon response JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=26539644 #FOAvip Attenuated measles virus (MV) is currently being evaluated as an oncolytic virus in clinical trials and could represent a new therapeutic approach for malignant pleural mesothelioma (MPM). Herein, we screened the sensitivity to MV infection and replication of twenty-two human MPM cell lines and some healthy primary cells. We show that MV replicates in fifteen of the twenty-two MPM cell lines. Despite overexpression of CD46 by a majority of MPM cell lines compared to healthy cells, we found that the sensitivity to MV replication did not correlate with this overexpression. We then evaluated the antiviral type I interferon (IFN) responses of MPM cell lines and healthy cells. We found that healthy cells and the seven insensitive MPM cell lines developed a type I IFN response in presence of the virus, thereby inhibiting replication. In contrast, eleven of the fifteen sensitive MPM cell lines were unable to develop a complete type I IFN response in presence of MV. Finally, we show that addition of type I IFN onto MV sensitive tumor cell lines inhibits replication. These results demonstrate that defects in type I IFN response are frequent in MPM and that MV takes advantage of these defects to exert oncolytic activity. Twit Text FOAVip Sensitivity of human pleural mesothelioma to oncolytic measles virus depends on defects of the type I interferon response ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=26539644 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26539644 #FOAvip English Wikipedia <ref>{{Cite pmid|26539644 }}</ref> Sensitivity of human pleural mesothelioma to oncolytic measles virus depends on defects of the type I interferon response #MMPMID26539644 Achard C ; Boisgerault N ; Delaunay T ; Roulois D ; Nedellec S ; Royer PJ ; Pain M ; Combredet C ; Mesel-Lemoine M ; Cellerin L ; Magnan A ; Tangy F ; Grégoire M ; Fonteneau JF Oncotarget 2015[Dec]; 6 (42 ): 44892-904 PMID26539644 show ga Attenuated measles virus (MV) is currently being evaluated as an oncolytic virus in clinical trials and could represent a new therapeutic approach for malignant pleural mesothelioma (MPM). Herein, we screened the sensitivity to MV infection and replication of twenty-two human MPM cell lines and some healthy primary cells. We show that MV replicates in fifteen of the twenty-two MPM cell lines. Despite overexpression of CD46 by a majority of MPM cell lines compared to healthy cells, we found that the sensitivity to MV replication did not correlate with this overexpression. We then evaluated the antiviral type I interferon (IFN) responses of MPM cell lines and healthy cells. We found that healthy cells and the seven insensitive MPM cell lines developed a type I IFN response in presence of the virus, thereby inhibiting replication. In contrast, eleven of the fifteen sensitive MPM cell lines were unable to develop a complete type I IFN response in presence of MV. Finally, we show that addition of type I IFN onto MV sensitive tumor cell lines inhibits replication. These results demonstrate that defects in type I IFN response are frequent in MPM and that MV takes advantage of these defects to exert oncolytic activity. |*Virus Replication [MESH] |Antigens, CD/metabolism [MESH] |Cell Adhesion Molecules/metabolism [MESH] |Cell Line, Tumor [MESH] |Host-Pathogen Interactions [MESH] |Humans [MESH] |Interferon Type I/immunology/*metabolism [MESH] |Measles virus/*growth & development/immunology/metabolism [MESH] |Membrane Cofactor Protein/metabolism [MESH] |Mesothelioma/immunology/metabolism/*therapy/virology [MESH] |Oncolytic Virotherapy/*methods [MESH] |Oncolytic Viruses/*growth & development/immunology/metabolism [MESH] |Pleural Neoplasms/immunology/metabolism/*therapy/virology [MESH] |Receptors, Cell Surface/metabolism [MESH] |Signal Transduction [MESH] |Signaling Lymphocytic Activation Molecule Family Member 1 [MESH]Sensitivity of human pleural mesothelioma to oncolytic measles virus d(epmc).pdf DeepDyve Pubget Overpricing