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10.1371/journal.pone.0150532

http://scihub22266oqcxt.onion/10.1371/journal.pone.0150532
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C4792534!4792534!26978269
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suck abstract from ncbi


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pmid26978269      PLoS+One 2016 ; 11 (3): ä
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  • Bronchiectasis as a Comorbidity of Chronic Obstructive Pulmonary Disease: A Systematic Review and Meta-Analysis #MMPMID26978269
  • Du Q; Jin J; Liu X; Sun Y
  • PLoS One 2016[]; 11 (3): ä PMID26978269show ga
  • Background: Bronchiectasis revealed by chest computed tomography in COPD patients and its comorbid effect on prognosis have not been addressed by large-sized studies. Understanding the presence of bronchiectasis in COPD is important for future intervention and preventing disease progression. Methods: Observational studies were identified from electronic literature searches in Cochrane library, PubMed, ScienceDirect databases, American Thoracic Society and European Respiratory Society meeting abstracts. A systematic review and meta-analysis of studies was performed to summarize the factors associated with bronchiectasis in COPD patients. Primary outcomes included the risks for exacerbation frequency, isolation of a potentially pathogenic microorganism, severe airway obstruction and mortality. Odds ratios (ORs) were pooled by random effects models. Results: Fourteen observational studies were eligible for the study. Compared with COPD without bronchiectasis, comorbid bronchiectasis in COPD increased the risk of exacerbation (1.97, 95% CI, 1.29?3.00), isolation of a potentially pathogenic microorganism (4.11, 95%CI, 2.16?7.82), severe airway obstruction (1.31, 95% CI, 1.09?1.58) and mortality (1.96, 95% CI, 1.04?3.70). Conclusions: The presence of bronchiectasis in patients with COPD was associated with exacerbation frequency, isolation of a potentially pathogenic microorganism, severe airway obstruction and mortality.
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